Blar i Bergen Open Research Archive på forfatter "Lille-Langøy, Roger"
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Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars)
Söderström, Sofie Karin; Lille-Langøy, Roger; Yadetie, Fekadu; Rauch, Mateusz; Milinski, Ana; Dejaegere, Annick; Stote, Roland H.; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2022)Toxicity mediated by per- and polyfluoroalkyl substances (PFAS), and especially perfluoroalkyl acids (PFAAs), has been linked to activation of peroxisome proliferator-activated receptors (Ppar) in many vertebrates. Here, ... -
Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) caged at a capped waste disposal site in Kollevåg, Western Norway
Dale, Karina; Müller, Mette Bjørge; Tairova, Zhanna; Khan, Essa Ahsan; Hatlen, Kristin; Grung, Merete; Yadetie, Fekadu; Lille-Langøy, Roger; Blaser, Nello; Skaug, Hans J; Lyche, Jan Ludvig; Arukwe, Augustine; Hylland, Ketil; Karlsen, Odd André; Goksøyr, Anders (Peer reviewed; Journal article, 2019)The aim of this study was to assess whether fish in Kollevåg, a sheltered bay on the western coast of Norway, previously utilized as a waste disposal site, could be affected by environmental contaminants leaking from the ... -
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently
Lille-Langøy, Roger; Goldstone, Jared; Rusten, Marte; Milnes, Matthew R.; Male, Rune; Stegeman, John J.; Blumberg, Bruce; Goksøyr, Anders (Peer reviewed; Journal article, 2015-04-01)Background Many persistent organic pollutants (POPs) accumulate readily in polar bears because of their position as apex predators in Arctic food webs. The pregnane X receptor (PXR, formally NR1I2, here proposed to be named ... -
Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)
Routti, Heli Anna Irmeli; Berg, Mari Katrine; Lille-Langøy, Roger; Øygarden, Lene Eidsvik; Harju, Mikael; Dietz, Rune; Sonne, Christian; Goksøyr, Anders (Peer reviewed; Journal article, 2019-05-06)Peroxisome proliferator-activated receptor alfa (PPARA/NR1C1) is a ligand activated nuclear receptor that is a key regulator of lipid metabolism in tissues with high fatty acid catabolism such as the liver. Here, we cloned ... -
Independent losses of a xenobiotic receptor across teleost evolution
Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K.; Lille-Langøy, Roger; Puntervoll, Pål; Goldstone, Jared V.; Jakobsen, Kjetill Sigurd; Stegeman, John; Goksøyr, Anders; Karlsen, Odd Andre (Peer reviewed; Journal article, 2018-07-10)Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fish genomes enable us to trace the evolution of defense genes in the largest and ... -
Modulation of neuro-dopamine homeostasis in juvenile female Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances
Khan, Essa Ahsan; Bertotto, Luisa B.; Dale, Karina; Lille-Langøy, Roger; Yadetie, Fekadu; Karlsen, Odd Andre; Goksøyr, Anders; Schlenk, Daniel; Arukwe, Augustine (Peer reviewed; Journal article, 2019)The dopaminergic effect of PAH and PFAS mixtures, prepared according to environmentally relevant concentrations, has been studied in juvenile female Atlantic cod (Gadus morhua). Benzo[a]pyrene, dibenzothiophene, fluorene, ... -
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
Tartu, Sabrina; Lille-Langøy, Roger; Størseth, Trond Røvik; Bourgeon, Sophie; Brunsvik, Anders; Goksøyr, Anders; Jenssen, Bjørn Munro; Polder, Anuschka; Thiemann, Gregory W.; Torget, Vidar; Routti, Heli (Peer reviewed; Journal article, 2017-11-28)There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for ... -
Nuclear receptor targets for environmental pollutants. Modulation of transcriptional activity of pregnane x receptor and peroxisome proliferator-activated receptor gamma in polar bears and zebrafish
Lille-Langøy, Roger (Doctoral thesis, 2016)Liganded nuclear receptors can be viewed as transcriptional dimmers whose activity is adjusted by molecular signals. Since the chemical footprint of humans continue to increase, the numbers of chemicals in the environment ... -
Polycyclic aromatic hydrocarbons modulate the activity of Atlantic cod (Gadus morhua) vitamin D receptor paralogs in vitro
Goksøyr, Siri Øfsthus; Goldstone, Jed; Lille-Langøy, Roger; Lock, Erik Jan Robert; Olsvik, Pål Asgeir; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Vitamin D receptor (VDR) mediates the biological function of the steroid hormone calcitriol, which is the metabolically active version of vitamin D. Calcitriol is important for a wide array of physiological functions, ... -
Population structure and history of North Atlantic Blue whales (Balaenoptera musculus musculus) inferred from whole genome sequence analysis
Jossey, Sushma; Haddrath, Oliver; Loureiro, Livia; Weir, Jason T.; Lim, Burton K.; Miller, Jacqueline; Scherer, Stephen W.; Goksøyr, Anders; Lille-Langøy, Roger; Kovacs, Kit M.; Lydersen, Christian; Routti, Heli Anna Irmeli; Engstrom, Mark D. (Journal article; Peer reviewed, 2024)Knowledge of genetic diversity and structure is essential for developing conservation strategies for endangered species. Blue whales were hunted to near extinction in the mid-twentieth century. Not-withstanding almost ... -
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)
Dale, Karina; Yadetie, Fekadu; Müller, Mette Helen Bjørge; Pampanin, Daniela Maria; Gilabert, Alejandra; Zhang, Xiaokang; Tairova, Zhanna; Haarr, Ane; Lille-Langøy, Roger; Lyche, Jan Ludvig; Porte, Cinta; Karlsen, Odd Andre; Goksøyr, Anders (Journal article; Peer reviewed, 2020)The aim of the present study was to investigate effects of defined mixtures of polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× = H) ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Xenobiotic metabolism and its physiological consequences in high‑Antarctic Notothenioid fishes
Strobel, Anneli; Lille-Langøy, Roger; Segner, Helmut; Burkhardt-Holm, Patricia; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2022)The Antarctic ecosystem is progressively exposed to anthropogenic contaminants, such as polycyclic aromatic hydrocarbons (PAHs). So far, it is largely unknown if PAHs leave a mark in the physiology of high-Antarctic fish. ...