Blar i Bergen Open Research Archive på forfatter "Lilleng, Peer Kåre"

Viser treff 1-8 av 8

    • Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo 

      Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan; Geisler, Stephanie; Staalesen, Vidar; Leirvaag, Beryl; Yndestad, Synnøve; de Faveri, Elise Norheim; Karlsen, Bård Ove; Wedge, David C.; Akslen, Lars A.; Lilleng, Peer Kåre; Løkkevik, Erik; Lundgren, Steinar; Østenstad, Bjørn; Risberg, Terje; Mjaaland, Ingvil; Aas, Turid; Lønning, Per Eystein (Peer reviewed; Journal article, 2015-10)
      Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as ...

    • Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Peer reviewed; Journal article, 2016-11-22)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...

    • Fatal injury as a function of rurality - a tale of two Norwegian counties 

      Bakke, Håkon Kvåle; Hansen, Ingrid Schrøder; Bendixen, Anette Bakkane; Morild, Inge; Lilleng, Peer Kåre; Wisborg, Torben (Peer reviewed; Journal article, 2013-03-02)
      Background: Many studies indicate rural location as a separate risk for dying from injuries. For decades, Finnmark, the northernmost and most rural county in Norway, has topped the injury mortality statistics in Norway. ...

    • High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function 

      Yndestad, Synnøve; Austreid, Eilin; Knappskog, Stian; Chrisanthar, Ranjan; Lilleng, Peer Kåre; Lønning, Per Eystein; Eikesdal, Hans Petter (Peer reviewed; Journal article, 2017)
      Purpose: PTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer ...

    • Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study 

      Björkman, Lars; Lundekvam, Birgitte F.; Lægreid, Torgils; Bertelsen, Bjørn I.; Morild, Inge; Lilleng, Peer Kåre; Lind, Birger; Palm, Brita; Vahter, Marie (Peer reviewed; Journal article, 2007-10-11)
      Background: The main forms of mercury (Hg) exposure in the general population are methylmercury (MeHg) from seafood, inorganic mercury (I-Hg) from food, and mercury vapor (Hg0) from dental amalgam restorations. While the ...

    • Molecular pathogenesis of polymerase gamma-related neurodegeneration 

      Tzoulis, Charalampos; Tran, Gia Tuong Thi; Coxhead, Jonathan; Bertelsen, Bjørn; Lilleng, Peer Kåre; Balafkan, Novin; Payne, Brendan; Miletic, Hrvoje; Chinnery, Patrick F.; Bindoff, Laurence (Peer reviewed; Journal article, 2014-07)
      Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ...

    • Utdanningsmodul i molekylærpatologi for leger som spesialiserer seg i patologifaget 

      Lilleng, Peer Kåre; Molven, Anders (UPED-skrift nr. 1/2004, Working paper, 2004)

    • Wear particles and ions from cemented and uncemented titanium-based hip prostheses-A histological and chemical analysis of retrieval material 

      Grosse, Susann; Haugland, Hans Kristian; Lilleng, Peer Kåre; Ellison, Peter; Hallan, Geir; Høl, Paul Johan (Peer reviewed; Journal article, 2014-07-23)
      Wear debris-induced inflammation is considered to be the main cause for periprosthetic osteolysis in total hip replacements (THR). The objective of this retrieval study was to examine the tissue reactions and exposure to ...