Browsing Bergen Open Research Archive by Author "Lindquist, Carine"
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Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats
Dankel, Simon Nitter; Kalleklev, Tine-Lise; Tungland, siri Lunde; Stafsnes, Marit Hallvardsdotter; Bruheim, Per; Aloysius, Thomas Aquinas; Lindquist, Carine; SKORVE, JON; Nygård, Ottar Kjell; Madsen, Lise; Bjørndal, Bodil; Sydnes, Magne Olav; Berge, Rolf Kristian (Journal article; Peer reviewed, 2023)Altered hepatic mitochondrial fatty acid β-oxidation and associated tricarboxylic acid (TCA) cycle activity contributes to lifestyle-related diseases, and circulating biomarkers reflecting these changes could have disease ... -
Hepatic Energy Metabolism Underlying Differential Lipidomic Responses to High-Carbohydrate and High-Fat Diets in Male Wistar Rats
Dankel, Simon N; Bjørndal, Bodil; Lindquist, Carine; Grinna, Mari Lausund; Rossmann, Christine Renate; Bohov, Pavol; Nygård, Ottar Kjell; Hallstrom, Seth; Strand, Elin; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Background Low-carbohydrate diets are suggested to exert metabolic benefits by reducing circulating triacylglycerol (TG) concentrations, possibly by enhancing mitochondrial activity. Objective We aimed to elucidate ... -
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-09-24)A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
Bjørndal, Bodil; Ramsvik, Marie Sannes; Lindquist, Carine; Nordrehaug, Jan Erik; Bruheim, Inge; Svardal, Asbjørn M.; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
Bjune, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Objective: Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ... -
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice
Berge, Rolf Kristian; Bjørndal, Bodil; Strand, Elin; Bohov, Pavol; Lindquist, Carine; Nordrehaug, Jan Erik; Svardal, Asbjørn; Skorve, Jon; Nygård, Ottar (Peer reviewed; Journal article, 2016-02-05)Background: Hepatic mitochondrial dysfunction plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methyl donor supplementation has been shown to alleviate NAFLD, connecting the condition ...