• Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum 

      Jenum, Synne; Sivakumaran, Dhanasekaran; Lodha, Rakesh; Mukherjee, Aparna; Saini, Deepak Kumar; Singh, Sarman; Singh, Varinder; Medigeshi, Guruprasad; Haks, Marielle C.; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Kabra, Sushil K.; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-01-04)
      The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ...
    • Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications 

      Martin, Helena; Falconer, Jennifer; Addo-Yobo, Emmanuel; Aneja, Satinder; Arroyo, Luis Martinez; Asghar, Rai; Awasthi, Shally; Banajeh, Salem; Bari, Abdul; Basnet, Sudha; Bavdekar, Ashish; Bhandari, Nita; Bhatnagar, Shinjini; Bhutta, Zulfiqar A.; Brooks, Abdullah; Chadha, Mandeep; Chisaka, Noel; Chou, Monidarin; Clara, Alexey W.; Colbourn, Tim; Cutland, Clare; D'Acremont, Valérie; Echavarria, Marcela; Gentile, Angela; Gessner, Brad; Gregory, Christopher J.; Hazir, Tabish; Hibberd, Patricia L.; Hirve, Siddhivinayak; Hooli, Shubhada; Iqbal, Imran; Jeena, Prakash; Kartasasmita, Cissy B.; King, Carina; Libster, Romina; Lodha, Rakesh; Lozano, Juan M.; Lucero, Marilla; Lufesi, Norman; MacLeod, William B.; Madhi, Shabir Ahmed; Mathew, Joseph L.; Maulen-Radovan, Irene; McCollum, Eric D.; Mino, Greta; Mwansambo, Charles; Neuman, Mark I.; Nguyen, Ngoc Tuong Vy; Nunes, Marta C.; Nymadawa, Pagbajabyn; O'Grady, Kerry-Ann F; Pape, Jean-William; Paranhos-Baccala, Glaucia; Patel, Archana; Picot, Valentina Sanchez; Rakoto-Andrianarivelo, Mala; Rasmussen, Zeba; Rouzier, Vanessa; Russomando, Graciela; Ruvinsky, Raul O.; Sadruddin, Salim; Saha, Samir K.; Santosham, Mathuram; Singhi, Sunit; Soofi, Sajid; Strand, Tor Arne; Sylla, Mariam; Thamthitiwat, Somsak; Thea, Donald M.; Turner, Claudia; Vanhems, Philippe; Wadhwa, Nitya; Wang, Jianwei; Zaman, Syed Ma; Campbell, Harry; Nair, Harish; Qazi, Shamim Ahmad; Nisar, Yasir Bin (Journal article; Peer reviewed, 2022)
      Background The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed ...
    • BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome 

      Jenum, Synne; Bakken, Rasmus; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; Lodha, Rakesh; Singh, Sarman; Singh, Varinder; Haks, Marielle C.; Ottenhoff, Tom H.M.; Kabra, Sushil K.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-12-12)
      Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification ...
    • External validation of the RISC, RISC-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia 

      Rees, Chris A.; Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; Mwansambo, Charles; Lazzerini, Marzia; Madhi, Shabir A.; Cutland, Clare; Nunes, Marta; Gessner, Bradford D.; Basnet, Sudha; Kartasasmita, Cissy B.; Mathew, Joseph L.; Zaman, Syed Mohammad Akram Uz; Paranhos-Baccalà, Gláucia; Bhatnagar, Shinjini; Wadhwa, Nitya; Lodha, Rakesh; Aneja, Satinder; Santosham, Mathuram; Picot, Valentina Sanchez; Sylla, Mariam; Awasthi, Shally; Bavdekar, Ashish; Pape, Jean-William; Rouzier, Vanessa; Chou, Monidarin; Rakoto-Andrianarivelo, Mala; Wang, Jianwei; Nymadawa, Pagbajabyn; Vanhems, Philippe; Russomando, Graciela; Asghar, Rai; Banajeh, Salem; Iqbal, Imran; MacLeod, William; Maulen-Radovan, Irene; Mino, Greta; Saha, Samir; Singhi, Sunit; Thea, Donald M; Clara, Alexey W.; Campbell, Harry; Nair, Harish; Falconer, Jennifer; Williams, Linda J.; Horne, Margaret; Strand, Tor Arne; Qazi, Shamim A.; Nisar, Yasir B.; Neuman, Mark I. (Journal article; Peer reviewed, 2021)
      Background: Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was to externally validate three such risk scores. Methods: We applied the ...
    • In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset 

      Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; Mwansambo, Charles; Gregory, Christopher J.; Thamthitiwat, Somsak; Cutland, Clare; Madhi, Shabir Ahmed; Nunes, Marta C.; Gessner, Bradford D.; Hazir, Tabish; Mathew, Joseph L.; Addo-Yobo, Emmanuel; Chisaka, Noel; Hassan, Mumtaz; Hibberd, Patricia L.; Jeena, Prakash; Lozano, Juan M.; MacLeod, William B.; Patel, Archana; Thea, Donald M.; Nguyen, Ngoc Tuong Vy; Zaman, Syed MA.; Ruvinsky, Raul O.; Lucero, Marilla; Kartasasmita, Cissy B.; Turner, Claudia; Asghar, Rai; Banajeh, Salem; Iqbal, Imran; Maulen-Radovan, Irene; Mino-Leon, Greta; Saha, Samir K.; Santosham, Mathuram; Singhi, Sunit; Awasthi, Shally; Bavdekar, Ashish; Chou, Monidarin; Nymadawa, Pagbajabyn; Pape, Jean-William; Paranhos-Baccala, Glaucia; Picot, Valentina Sanchez; Rakoto-Andrianarivelo, Mala; Rouzier, Vanessa; Russomando, Graciela; Sylla, Mariam; Vanhems, Philippe; Wang, Jianwei; Basnet, Sudha; Strand, Tor Arne; Neuman, Mark I.; Arroyo, Luis Martinez; Echavarria, Marcela; Bhatnagar, Shinjini; Wadhwa, Nitya; Lodha, Rakesh; Aneja, Satinder; Gentile, Angela; Chadha, Mandeep; Hirve, Siddhivinayak; O'Grady, Kerry-Ann F.; Clara, Alexey W.; Rees, Chris A.; Campbell, Harry; Nair, Harish; Falconer, Jennifer; Williams, Linda J.; Horne, Margaret; Qazi, Shamim A.; Nisar, Yasir Bin (Journal article; Peer reviewed, 2023)
      Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing pneumonia in-hospital mortality risk factors. Methods: We report the characteristics and ...
    • Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children 

      Gjøen, John Espen; Jenum, Synne; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; MacAden, Ragini; Kabra, Sushil K.; Lodha, Rakesh; Ottenhoff, Tom H.M.; Haks, Marielle C.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2017-07-19)
      Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ...
    • Predictors of time to recovery in infants with probable serious bacterial infection 

      Singh, Prashant; Wadhwa, Nitya; Lodha, Rakesh; Sommerfelt, Halvor; Aneja, Satinder; Natchu, Uma Chandra Mouli; Chandra, Jagdish; Rath, Bimbadhar; Sharma, Vinod Kumar; Kumari, Mohini; Saini, Saviti; Kabra, Sushil K.; Bhatnagar, Shinjini; Strand, Tor A. (Peer reviewed; Journal article, 2015-04-24)
      Introduction: Serious bacterial infections continue to be an important cause of death and illness among infants in developing countries. Time to recovery could be considered a surrogate marker of severity of the infection. ...
    • Xpert MTB/RIF assay can be used on archived gastric aspirate and induced sputum samples for sensitive diagnosis of paediatric tuberculosis 

      Singh, Sarman; Singh, Amit; Prajapati, Suneel; Kabra, Sushil K.; Lodha, Rakesh; Mukherjee, Aparna; Singh, Varinder; Hesseling, Anneke C.; Grewal, Harleen (Peer reviewed; Journal article, 2015-09-29)
      Background: Tuberculosis (TB) in children is neglected, mainly due to lack of sensitive diagnostic tools. Recently Xpert MTB/RIF assay has revolutionized the diagnostic field, but its usefulness in pediatric TB has not ...