Blar i Bergen Open Research Archive på forfatter "Lorenz, Susanne"
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Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Georgiesh, Tatiana; Namløs, Heidi Maria; Sharma, Nitin; Lorenz, Susanne; Myklebost, Ola; Bjerkehagen, Bodil; Meza-Zepeda, Leonardo A.; Boye, Kjetil (Journal article; Peer reviewed, 2021)Solitary fibrous tumour (SFT) is a mesenchymal neoplasm characterised by pathognomonic NAB2-STAT6 gene fusions. The clinical implications and prognostic value of different fusion variants has not been clarified. In the ... -
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Reint, Ganna; Li, Zhuokun; Labun, Kornel; Keskitalo, Salla; Soppa, Inkeri; Mamia, Katariina Aino Inkeri; Tolo, Eero; Szymanska, Monika; Meza-Zepeda, Leonardo A.; Lorenz, Susanne; Cieslar-Pobuda, Artur Grzegorz; Hu, Xian; Bodin, Diana L; Staerk, Judith; Valen, Eivind Dale; Schmierer, Bernhard; Varjosalo, Markku; Taipale, Jussi; Haapaniemi, Emma Maria (Journal article; Peer reviewed, 2021)Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the ... -
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Vodak, Daniel; Lorenz, Susanne; Nakken, Sigve; Aasheim, Lars Birger; Holte, Harald; Bai, Baoyan; Myklebost, Ola; Meza, Leonardo Zepeda; Hovig, Eivind (Peer reviewed; Journal article, 2018-03-28)Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described ... -
The visual framing of climate change impacts and adaptation in the IPCC assessment reports
Wardekker, Arjan; Lorenz, Susanne (Journal article; Peer reviewed, 2019)The Intergovernmental Panel on Climate Change (IPCC) is a key source on climate change information. How the IPCC presents and frames this climate information influences how policymakers and various stakeholders worldwide ...