Browsing Bergen Open Research Archive by Author "Lu, Ning"
Now showing items 1-6 of 6
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Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
Österholm, Cecilia; Lu, Ning; Lidén, Åsa; Karlsen, Tine V.; Gullberg, Donald; Reed, Rolf K.; Kusche-Gullberg, Marion (Peer reviewed; Journal article, 2012-07-25)Background: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan ... -
Fibroblast α11β1 Integrin Regulates Tensional Homeostasis in Fibroblast/A549 Carcinoma Heterospheroids
Lu, Ning; Karlsen, Tine Veronica; Reed, Rolf K.; Kusche-Gullberg, Marion; Gullberg, Donald (Peer reviewed; Journal article, 2014-07-30)We have previously shown that fibroblast expression of α11β1 integrin stimulates A549 carcinoma cell growth in a xenograft tumor model. To understand the molecular mechanisms whereby a collagen receptor on fibroblast can ... -
Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation
Murugan Erusappan, Pugazendhi; Alam, Jahedul; Lu, Ning; Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2019)Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ... -
Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts
Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning; Svendsen, Agnete; Reed, Rolf K.; Garmann-Johnsen, Annette; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2017-08-23)Background: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and ... -
Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors
Smeland, Hilde Ytre-Hauge; Lu, Ning; Karlsen, Tine Veronica; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2019-03-15)Background: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the ... -
α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration
Zeltz, Cedric; Alam, Jahedul; Liu, Hengshuo; Erusappan, Pugazendhi M; Hoschuetzky, Heinz; Molven, Anders; Parajuli, Himalaya; Cukierman, Edna; Costea, Daniela Elena; Lu, Ning; Gullberg, Donald (Peer reviewed; Journal article, 2019-06-01)Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further ...