• Composite immune marker scores associated with severe mental disorders and illness course 

      Ormerod, Monica Bettina E. Greenwood; Ueland, Thor; Werner, Maren Caroline Frogner; Hjell, Gabriela; Rødevand, Linn Nilsen; Sæther, Linn Sofie; Lunding, Synve Hoffart; Johansen, Ingrid Torp; Ueland, Torill; Lagerberg, Trine Vik; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have ...
    • Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica Bettina E. Greenwood; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ...
    • Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Nils Eiel (Journal article; Peer reviewed, 2020)
      Background One third of people diagnosed with schizophrenia fail to respond adequately to antipsychotic medication, resulting in persisting disabling symptoms, higher rates of hospitalization and higher costs for society. ...
    • Interleukin-18 signaling system links to agitation in severe mental disorders 

      Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia; Bell, Christina; Fischer-Vieler, Thomas; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart; Ormerod, Monica Bettina E. Greenwood; Johansen, Ingrid Torp; Dieset, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel; Haukvik, Unn Kristin Hansen (Journal article; Peer reviewed, 2022)
      Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and ...
    • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. ...