Browsing Bergen Open Research Archive by Author "Lybak, Stein"
Now showing items 1-10 of 10
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The acute phase reaction and its prognostic impact in patients with head and neck squamous cell carcinoma: Single biomarkers including c-reactive protein versus biomarker profiles
Aarstad, Helene Hersvik; Moe, Svein Erik Emblem; Bruserud, Øystein; Lybak, Stein; Aarstad, Hans Jørgen; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2020)C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines ... -
Ameloblastic carcinoma of the mandible: A case report and literature review
Brukas, Mindaugas; Pedersen, Torbjørn Østvik; Lybak, Stein; Skarstein, Kathrine; Løes, Sigbjørn Suk (Journal article; Peer reviewed, 2020)Ameloblastic carcinoma is a rare malignant odontogenic tumor. Here we present a case of malignant transformation of ameloblastoma into ameloblastic carcinoma over a period of eight years. A cystic lesion in the left mandible ... -
Combined in situ hybridization and immunohistochemistry on archival tissues reveals stromal microRNA-204 as prognostic biomarker for oral squamous cell carcinoma
Rajthala, Saroj; Dongre, Harsh; Parajuli, Himalaya; Min, Anjie; Nginamau, Elisabeth Sivy; Kvalheim, Arild; Lybak, Stein; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Micro-RNAs (miRs) are emerging as important players in carcinogenesis. Their stromal expression has been less investigated in part due to lack of methods to accurately differentiate between tumor compartments. This study ... -
Integrin a11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression
Parajuli, Himalaya; Teh, Muy-Teck; Abrahamsen, Siren; Christoffersen, Ingeborg Monge; Neppelberg, Evelyn; Lybak, Stein; Osman, Tarig Al-Hadi; Johannessen, Anne Christine; Gullberg, Donald; Skarstein, Kathrine; Costea, Daniela Elena (Peer reviewed; Journal article, 2017-04)BACKGROUND: Cancer-associated fibroblasts (CAFs) were shown to be important for tumour progression in head and neck squamous cell carcinomas (HNSCCs). Their heterogeneity and lack of specific markers is increasingly ... -
MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells
Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ... -
Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility
Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ... -
Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer.
Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; Jacobsen, Hege Karine; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian (Peer reviewed; Journal article, 2014-12)Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ... -
Temporomandibular joint prosthesis in cancer reconstruction preceding radiation therapy
Pedersen, Torbjørn Østvik; Lybak, Stein; Lund, Bodil Kristina; Løes, Sigbjørn Suk (Journal article; Peer reviewed, 2021)Total joint prostheses are a viable treatment option after removal of malignancies invading the temporomandibular joint, even when adjuvant radiation therapy is required. -
The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients
Moe, Svein Erik Emblem; Erland, Fredrik Atteraas; Fromreide, Siren; Lybak, Stein; Brydøy, Marianne; Dongre, Harsh Nitin; Manueldas, Sophia; Costea, Daniela Elena; Vintermyr, Olav Karsten; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2023-06-26)Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 mutations relative to the presence of human papillomavirus ... -
Tumor infiltration levels of CD3, Foxp3 (+) lymphocytes and CD68 macrophages at diagnosis predict 5-year disease-specific survival in patients with oropharynx squamous cell carcinoma
Ljøkjel, Borghild; Haave, Hilde; Lybak, Stein; Vintermyr, Olav Karsten; Helgeland, Lars; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2022)Head and neck cancer (HNC) is the sixth most common cancer worldwide. Oropharyngeal (OP) cancers are of special interest because of possible underlying HPV infection which is tied to prognosis. Influxes of inflammatory ...