Browsing Bergen Open Research Archive by Author "Lynagh, Timothy Peter"
Now showing items 1-5 of 5
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Comparative analysis defines a broader FMRFamide-gated sodium channel family and determinants of neuropeptide sensitivity
Dandamudi, Mowgli; Hausen, Harald; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2022)FMRFamide (Phe-Met-Arg-Phe-amide, FMRFa) and similar neuropeptides are important physiological modulators in most invertebrates, but the molecular basis of FMRFa activity at its receptors is unknown. We therefore sought ... -
Constitutive activity of ionotropic glutamate receptors via hydrophobic substitutions in the ligand-binding domain
Seljeset, Sandra; Sintsova, Oksana Vladimirovna; Wang, Yuhong; Harb, Hassan Y.; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2024)Neurotransmitter ligands electrically excite neurons by activating ionotropic glutamate receptor (iGluR) ion channels. Knowledge of the iGluR amino acid residues that dominate ligand-induced activation would enable the ... -
Loss of activation by GABA in vertebrate delta ionotropic glutamate receptors
Rosano, Giulio; Barzasi, Allan; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2024)Ionotropic glutamate receptors (iGluRs) mediate excitatory signals between cells by binding neurotransmitters and conducting cations across the cell membrane. In the mammalian brain, most of these signals are mediated by ... -
Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution
Marti Solans, Josep; Børve, Aina; Bump, Paul; Hejnol, Andreas; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2023)Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, ... -
Structural basis for excitatory neuropeptide signaling
Kalienkova, Valeriia; Dandamudi, Mowgli; Paulino, Cristina; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2024)Rapid signaling between neurons is mediated by ligand-gated ion channels, cell-surface proteins with an extracellular ligand-binding domain and a membrane-spanning ion channel domain. The degenerin/epithelial sodium channel ...