• Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease 

      Grødem, Jodi Maple; Dalen, Ingvild; Tysnes, Ole-Bjørn; Macleod, Angus D.; Forsgren, Lars; Counsell, Carl E.; Alves, Guido Werner (Journal article; Peer reviewed, 2021)
      Objective To establish the significance of glucocerebrosidase gene (GBA) carrier status on motor impairment in a large cohort of patients with incident Parkinson disease (PD). Methods Three European population-based ...
    • Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients 

      Szwedo, Aleksandra A; Pedersen, Camilla C; Ushakova, Anastasia; Forsgren, Lars; Tysnes, Ole-Bjørn; Counsell, Carl E.; Alves, Guido Werner; Lange, Johannes; Macleod, Angus D.; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2021)
      Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based ...
    • Early constipation predicts faster dementia onset in Parkinson's disease 

      Camacho, Marta; Macleod, Angus D.; Grødem, Jodi Maple; Evans, Jonathan R.; Breen, David P.; Cummins, G; Wijeyekoon, Ruwani; Greenland, Julia; Alves, Guido Werner; Tysnes, Ole-Bjørn; Lawson, Rachel A.; Barker, Roger A.; Williams-Gray, Caroline H. (Journal article; Peer reviewed, 2021)
      Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ...
    • Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts 

      Grødem, Jodi Maple; Paul, Kimberly C.; Dalen, Ingvild; Ngo, Kathie J.; Wong, Darice; Macleod, Angus D.; Counsell, Carl E.; Bäckström, David; Forsgren, Lars; Tysnes, Ole-Bjørn; Kusters, Cynthia D.J.; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Alves, Guido Werner (Journal article; Peer reviewed, 2021)
      Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ...