Browsing Bergen Open Research Archive by Author "Madsen, Lise"
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Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells
Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Peer reviewed; Journal article, 2012-03-27)Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ... -
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice
Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi; Meugnier, Emmanuelle; Battistoni, Brigitte Le Magueresse; Frøyland, Livar; Madsen, Lise; Jessen, Niels; Lund, Sten; Vidal, Hubert; Ruzzin, Jérôme (Peer reviewed; Journal article, 2011-09-23)Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ... -
Co-occurrence of contaminants in marine fish from the North East Atlantic Ocean: Implications for human risk assessment
Ho, Quang Tri; Bank, Michael; Mahjour Azad, Atabak; Nilsen, Bente Merete; Frantzen, Sylvia; Boitsov, Stepan; Måge, Amund; Kögel, Tanja; Sanden, Monica; Frøyland, Livar; Hannisdal, Rita; Hove, Helge Torbjørn; Lundebye, Anne-Katrine; Nøstbakken, Ole Jakob; Madsen, Lise (Journal article; Peer reviewed, 2021)Marine fish from the North East Atlantic Ocean (NEAO) are nutrient rich and considered a valuable economic resource. However, marine fish are also a major dietary source of several contaminants, including persistent organic ... -
Commercially available kelp and seaweed products – valuable iodine source or risk of excess intake?
Aakre, Inger; Solli, Dina Doblaug; Markhus, Maria Wik; Mæhre, Hanne K; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Korneliussen, Patrick-Andre; Madsen, Lise; Kjellevold, Marian (Journal article; Peer reviewed, 2021)Background: Seaweeds and kelps, also known as macroalgae, have long been common in the East-Asian diet. During recent years, macroalgae have entered the global food market, and a variety of macroalgae products are now ... -
Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean
Ho, Quang Tri; Frantzen, Sylvia; Nilsen, Bente Merete; Nøstbakken, Ole Jakob; Mahjour Azad, Atabak; Duinker, Arne; Madsen, Lise; Bank, Michael (Journal article; Peer reviewed, 2023)Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ... -
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet
Alvheim, Anita Røyneberg; Torstensen, Bente Elisabeth; Lin, Yu Hong; Lillefosse, Haldis Haukås; Lock, Erik-Jan; Madsen, Lise; Frøyland, Livar; Hibbeln, Joseph R.; Malde, Marian Kjellevold (Peer reviewed; Journal article, 2014-01)Dietary intake of linoleic acid (LNA, 18:2n-6) has increased dramatically during the 20th century and is associated with greater prevalence of obesity. The endocannabinoid system is involved in regulation of energy balance ... -
Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice
Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Rasinger, Josef; Lie, Kai Kristoffer; Bernhard, Annette; Madsen, Lise; Nøstbakken, Ole Jakob (Journal article; Peer reviewed, 2022-10-13)Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ... -
Effects of Frozen Storage on Phospholipid Content in Atlantic Cod Fillets and the Influence on Diet-Induced Obesity in Mice
Fauske, Kristin Røen; Bernhard, Annette; Fjære, Even; Myrmel, Lene Secher; Frøyland, Livar; Kristiansen, Karsten; Liaset, Bjørn; Madsen, Lise (Peer reviewed; Journal article, 2018-05-30)A large fraction of the n-3 polyunsaturated fatty acids (PUFAs) in cod fillet is present in the form of phospholipids (PLs). Freezing initiates hydrolysis of the PLs present in the fillet. Here, we compared the effects of ... -
Effects of geography and species variation on selenium and mercury molar ratios in Northeast Atlantic marine fish communities
Azad, Atabak Mahjour; Frantzen, Sylvia; Bank, Michael; Nilsen, Bente Merete; Duinker, Arne; Madsen, Lise; Måge, Amund (Peer reviewed; Journal article, 2019-11-01)Methylmercury (MeHg) is a potent neurotoxin that bioaccumulates in seafood. Co-occurrence of selenium (Se) may affect the bioavailability and toxicity of MeHg in organisms. Here we report the concentrations of total mercury ... -
The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice
Myrmel, Lene Secher; Fauske, Kristin Røen; Fjære, Even; Bernhard, Annette; Liisberg, Ulrike; Hasselberg, Astrid Elise; Øyen, Jannike; Kristiansen, Karsten; Madsen, Lise (Peer reviewed; Journal article, 2019-05-23)Low-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and ... -
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; Kristiansen, K.; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove (Peer reviewed; Journal article, 2017-02)Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ... -
Iodine status and thyroid function in a group of seaweed consumers in Norway
Aakre, Inger; Evensen, Lidunn Tveito; Kjellevold, Marian; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Madsen, Lise; Markhus, Maria Wik (Journal article; Peer reviewed, 2020)Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. ... -
Mercury bioaccumulation pathways in tusk (Brosme brosme) from Sognefjord, Norway: Insights from C and N isotopes
Mahjour Azad, Atabak; Frantzen, Sylvia; Bank, Michael; Madsen, Lise; Måge, Amund (Journal article; Peer reviewed, 2020-11)Seafood is the main source of methylmercury (MeHg) exposure for humans and elevated total mercury (Hg) concentrations have been reported in marine fish from Norwegian fjords compared with offshore areas. Hg in tusk fillets ... -
Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity
Mahjour Azad, Atabak; Bernhard, Annette; Shen, Anne; Myrmel, Lene Secher; Lundebye, Anne-Katrine; Lecaudey, Laurene Alicia; Fjære, Even; Ho, Quang Tri; Sveier, Harald; Kristiansen, Karsten; Limborg, Morten Tønsberg; Madsen, Lise (Journal article; Peer reviewed, 2023)Alternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally farmed blue mussels may represent an environmentally sustainable substitute with a lower carbon ... -
One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects
Ersland, Kari Merete; Myrmel, Lene Secher; Fjære, Even; Berge, Rolf Kristian; Madsen, Lise; Steen, Vidar Martin; Skrede, Silje (Peer reviewed; Journal article, 2019-05)Background: Antipsychotic drugs can negatively affect the metabolic status of patients, with olanzapine as one of the most potent drugs. While patients are often medicated for long time periods, experiments in rats typically ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
Bjune, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Objective: Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ... -
RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice
Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Lie, Kai Kristoffer; Rasinger, Josef; Madsen, Lise; Nøstbakken, Ole Jakob (Journal article; Peer reviewed, 2021)Methylmercury (MeHg) is a highly neurotoxic form of mercury (Hg) present in seafood. Here, we recorded and compared proteomic and transcriptomic changes in hippocampus of male BALB/c mice exposed to two doses of MeHg. Mice ... -
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance
Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona Synnøve; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ... -
Spatial distribution of mercury in seawater, sediment, and seafood from the Hardangerfjord ecosystem, Norway
Azad, Atabak Mahjour; Frantzen, Sylvia; Bank, Michael; Johnsen, Ingrid Askeland; Tessier, Emmanuel; Amouroux, David; Madsen, Lise; Måge, Amund (Peer reviewed; Journal article, 2019-06-01)Hardangerfjord is one of the longest fjords in the world and has historical mercury (Hg) contamination from a zinc plant in its inner sector. In order to investigate the extent of Hg transferred to abiotic and biotic ... -
Temporal variations in the nutrient content of Norwegian farmed Atlantic salmon (Salmo salar), 2005–2020
Reksten, Amalie Moxness; Ho, Quang Tri; Nøstbakken, Ole Jakob; Markhus, Maria Wik; Kjellevold, Marian; Bøkevoll, Annbjørg; Hannisdal, Rita; Frøyland, Livar; Madsen, Lise; Dahl, Lisbeth (Journal article; Peer reviewed, 2022)The changes in the feed of farmed Atlantic salmon (Salmo salar) towards a more plant-based diet affect the nutritional value of the fillets. By compiling the contents of a range of nutrients in 1108 samples of Norwegian ...