• Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway 

      Øyen, Nina; Olsen, Sjurdur Frodi; Basit, Saima; Leirgul, Elisabeth; Strøm, Marin; Carstensen, Lisbeth; Granström, Charlotta; Tell, Grethe S.; Magnus, Per; Vollset, Stein Emil; Wohlfart, Jan; Melbye, Mads (Peer reviewed; Journal article, 2019-03-19)
      Background: Evidence linking individual‐level maternal folic acid supplementation to offspring risk of congenital heart defects is lacking. We investigated whether folic acid supplementation in early pregnancy reduces ...
    • The autism birth cohort (ABC): A study of autism spectrum disorders in MoBa 

      Suren, Pål; Schjølberg, Synnve; Øyen, Anne-Siri; Lie, Kari Kveim; Hornig, Mady; Bresnahan, Michaeline; Bakke, Therese Wardenær; Roth, Christine; Alsaker, Elin Hilde Roti; Schreuder, Patricia; Stenberg, Nina; Reichborn-Kjennerud, Ted; Hirtz, Deborah; Susser, Ezra; Magnus, Per; Lipkin, Ian; Stoltenberg, Camilla (Peer reviewed; Journal article, 2014)
      Background: Autism spectrum disorders (ASDs) are characterized by persistent deficits in social communication and interaction and restricted, repetitive patterns of behavior, interests or activities. In most cases, the ...
    • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 

      Lee, Yunsung; Løkås Haftorn, Kristine; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian; Moen, Gunn-Helen; Magnus, Maria C.; Gjessing, Håkon K.; Harris, Jennifer R.; Magnus, Per; Håberg, Siri E.; Jugessur, Astanand; Bohlin, Jon; Lyle, Robert; Lee-Ødegård, Sindre; Groop, Leif C.; Prasad, Rashmi B.; Sletner, Line; Sommer, Christine (Journal article; Peer reviewed, 2020)
      Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina ...
    • Candidate gene analysis of spontaneous preterm delivery: New insights from re-analysis of a case-control study using case-parent triads and control-mother dyads 

      Myking, Solveig; Myhre, Ronny; Gjessing, Håkon K.; Morken, Nils-Halvdan; Sengpiel, Verena; Williams, Scott M.; Ryckman, Kelli K.; Magnus, Per; Jacobsson, Bo (Peer reviewed; Journal article, 2011-12-30)
      Background: Spontaneous preterm delivery (PTD) has a multifactorial etiology with evidence of a genetic contribution to its pathogenesis. A number of candidate gene case-control studies have been performed on spontaneous ...
    • Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births 

      Philips, Elise M.; Santos, Susana; Trasande, Leonardo; Aurrekoetxea, Juan J.; Barros, Henrique; von Berg, Andrea; Bergström, Anna; Bird, Philippa K.; Brescianini, Sonia; Chaoimh, Carol Ní; Charles, Marie-Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P.; Costet, Nathalie; Criswell, Rachel Louise; Crozier, Sarah; Eggesbø, Merete Åse; Fantini, Maria Pia; Farchi, Sara; Forastiere, Francesco; van Gelder, Marleen M.H.J.; Georgiu, Vagelis; Godfrey, Keith M.; Gori, Davide; Hanke, Wojciech; Heude, Barbara; Hryhorczuk, Daniel; Iñiguez, Carmen; Inskip, Hazel M.; Karvonen, Anne M.; Kenny, Louise C.; Kull, Inger; Lawlor, Debbie A.; Lehmann, Irina; Magnus, Per; Manios, Yannis; Melén, Erik; Mommers, Monique; Morgen, Camilla Schmidt; Moschonis, George; Murray, Deirdre; Nohr, Ellen A.; Nybo Andersen, Anne-Marie; Oken, Emily; Oostvogels, Adriëtte J.J.M.; Papadopoulou, Eleni Zoumpoulia; Pekkanen, Juha; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas-Shiman, Sheryl L.; Roeleveld, Nel; Rusconi, Franca; Santos, Ana C.; Sørensen, Thorkild I.A.; Standl, Marie; Stoltenberg, Camilla; Sunyer, Jordi; Thiering, Elisabeth; Thijs, Carel; Torrent, Maties; Vrijkotte, Tanja G.M.; Wright, John; Zvinchuk, Oleksandr; Gaillard, Romy; Jaddoe, Vincent W.V. (Journal article; Peer reviewed, 2020)
      Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke ...
    • Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium 

      Felix, Janine F.; Joubert, Bonnie R.; Baccarelli, Andrea A.; Sharp, Gemma C.; Almqvist, Catarina; Annesi-Maesano, Isabella; Arshad, Hasan; Baïz, Nour; Bakermans-Kranenburg, Marian J.; Bakulski, Kelly M.; Binder, Elisabeth B.; Bouchard, Luigi; Breton, Carrie V.; Brunekreef, Bert; Brunst, Kelly J.; Burchard, Esteban G.; Bustamante, Mariona; Chatzi, Leda; Munthe-Kaas, Monica Cheng; Corpeleijn, Eva; Czamara, Darina; Dabelea, Dana; Smith, George Davey; De Boever, Patrick; Duijts, Liesbeth; Dwyer, Terence; Eng, Celeste; Eskenazi, Brenda; Everson, Todd M.; Falahi, Fahimeh; Fallin, M. Daniele; Farchi, Sara; Fernández, Mariana F.; Gao, Lu; Gaunt, Tom R.; Ghantous, Akram; Gillman, Matthew W.; Gonseth, Semira; Grote, Veit; Gruzieva, Olena; Håberg, Siri Eldevik; Herceg, Zdenko; Hivert, Marie-France; Holland, Nina; Holloway, John W.; Hoyo, Cathrine; Hu, Donglei; Huang, Rae-Chi; Huen, Karen; Järvelin, Marjo-Riitta; Jima, Dereje D.; Just, Allan C.; Karagas, Margaret R.; Magnus, Per; Nystad, Wenche; Page, Christian; Lie, Rolv T.; Magnus, Maria Christine (Peer reviewed; Journal article, 2018-02)
    • Comorbidities treated in primary care in children with chronic fatigue syndrome 

      Bakken, Inger Johanne; Tveito, Kari; Aaberg, Kari Modalsli; Ghaderi, Sara; Gunnes, Nina; Trogstad, Lill; Magnus, Per; Stoltenberg, Camilla; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2016-09-02)
      Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex condition. Causal factors are not established, although underlying psychological or immunological susceptibility has been proposed. We ...
    • Diet matters, particularly in pregnancy - results from MoBa studies of maternal diet and pregnancy outcomes 

      Brantsæter, Anne Lise; Haugen, Margaretha; Myhre, Ronny; Sengpiel, Verena; Englund-Ögge, Linda; Nilsen, Roy Miodini; Borgen, Iren; Duarte-Salles, Talita; Papadopoulou, Eleni; Vejrup, Kristine; von Ruesten, Anne; Hillesund, Elisabet Rudjord; Birgisdottir, Bryndis Eva; Magnus, Per; Trogstad, Lill; Jacobsson, Bo; Bacelis, Jonas; Myking, Solveig; Knutsen, Helle Katrine; Kvalem, Helen Engelstad; Alexander, Jan; Mendez, Michelle; Meltzer, Helle Margrete (Peer reviewed; Journal article, 2014)
      Awareness that maternal diet may influence the outcome of pregnancy as well as the long-term health of mother and child has increased in recent years. A new food frequency questionnaire (FFQ) was developed and validated ...
    • Eating disorders, pregnancy, and the postpartum period: findings from the Norwegian Mother and Child Cohort Study (MoBa) 

      Watson, Hunna J.; Torgersen, Leila; Zerwas, Stephanie; Reichborn-Kjennerud, Ted; Knoph, Cecilie; Stoltenberg, Camilla; Siega-Riz, Anna Maria; Von Holle, Ann; Hamer, Robert M.; Meltzer, Helle Margrete; Ferguson, Elizabeth H.; Haugen, Margaretha; Magnus, Per; Kuhns, Rebecca; Bulik, Cynthia M. (Peer reviewed; Journal article, 2014)
      This review summarizes studies on eating disorders in pregnancy and the postpartum period that have been conducted as part of the broader Norwegian Mother and Child Cohort Study (MoBa). Prior to the 2000s, empirical ...
    • Epigenome-wide association study of leukocyte telomere length 

      Lee, Yunsung; Sun, Dianjianyi; Ori, Anil P.S.; Lu, Ake T.; Seeboth, Anne; Harris, Sarah E.; Deary, Ian J.; Marioni, Riccardo E.; Sørensen, Mette; Mengel-From, Jonas; Hjelmborg, Jacob; Christensen, Kaare; Wilson, James G.; Levy, Daniel; Reiner, Alex P.; Chen, Wei; Li, Shengxu; Harris, Jennifer Ruth; Magnus, Per; Aviv, Abraham; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)
      Telomere length is associated with age-related diseases and is highly heritable. It is unclear, however, to what extent epigenetic modifications are associated with leukocyte telomere length (LTL). In this study, we conducted ...
    • Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study 

      Sengpiel, Verena; Bacelis, Jonas; Myhre, Ronny; Myking, Solveig; Pay, Aase Serine Devold; Haugen, Margaretha; Brantsæter, Anne Lise; Meltzer, Helle Margrethe; Nilsen, Roy Miodini; Magnus, Per; Vollset, Stein Emil; Nilsson, Staffan; Jacobsson, Bo (Peer reviewed; Journal article, 2014-11-02)
      Background: Health authorities in numerous countries recommend periconceptional folic acid supplementation to prevent neural tube defects. The objective of this study was to examine the association of dietary folate intake ...
    • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 

      Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda (Journal article; Peer reviewed, 2020)
      Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ...
    • Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth 

      Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas; Jacobsson, Bo; Lindekleiv, Haakon; Hveem, Kristian; Lie, Rolv T.; Knudsen, Gun Peggy Strømstad; Stoltenberg, Camilla; Magnus, Per; Sagen, Jørn V.; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2019-10-01)
      Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 ...
    • Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania 

      Santos, Susana; Eekhout, Iris; Voerman, Ellis; Eggesbø, Merete Åse; Magnus, Per; Papadopoulou, Eleni Zoumpoulia; Stoltenberg, Camilla; Jaddoe, Vincent W V (Peer reviewed; Journal article, 2018-11-05)
      Background Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different ...
    • Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway 

      Ghaderi, Sara; Berg-Hansen, Pål; Bakken, Inger Johanne Landsjøåsen; Magnus, Per; Trogstad, Lill; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2020)
      Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. ...
    • How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa) 

      Cheesman, Rosa; Eilertsen, Espen Moen; Ahmadzadeh, Yasmin I.; Gjerde, Line C.; Hannigan, Laurie John; Havdahl, Alexandra; Young, Alexander I.; Eley, Thalia C.; Njølstad, Pål Rasmus; Magnus, Per; Andreassen, Ole Andreas; Ystrøm, Eivind; McAdams, Tom A. (Journal article; Peer reviewed, 2020)
      Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and ...
    • How to evaluate the effect of seven years of The Norwegian School Fruit Scheme (2007-14) on fruit, vegetables, snacks consumption and weight status- A natural experiment. 

      Hovdenak, Ingrid Marie; Stea, Tonje Holte; Magnus, Per; Krokstad, Steinar; Samdal, Oddrun; Bere, Elling Tufte (Journal article; Peer reviewed, 2019)
      Aim: From August 2007 to June 2014, the Norwegian School Fruit Scheme (NSFS) legally established that all pupils in junior high and combined schools (275,000 pupils every year), but not those in primary schools (343,000 ...
    • Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study 

      Monsen, Anne Lise Bjørke; Ulvik, Arve; Nilsen, Roy Miodini; Midttun, Øivind; Roth, Christine; Magnus, Per; Stoltenberg, Camilla; Vollset, Stein Emil; Reichborn-Kjennerud, Ted; Ueland, Per Magne (Peer reviewed; Journal article, 2016-11-30)
      Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, ...
    • Intake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in ofspring: a Norwegian pregnancy cohort study 

      Grønning Dale, Maria Teresa; Magnus, Per; Leirgul, Elisabeth; Holmstrøm, Henrik; Gjessing, Håkon K.; Brodwall, Kristoffer; Haugen, Margaretha; Stoltenberg, Camilla; Øyen, Nina (Peer reviewed; Journal article, 2019)
      Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened ...
    • Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis 

      Voerman, Ellis; Santos, Susana; Golab, Bernadeta Patro; Eggesbø, Merete Åse; Iszatt, Nina; Magnus, Per; Papadopoulou, Eleni Zoumpoulia; Stoltenberg, Camilla; Jaddoe, Vincent W.V. (Peer reviewed; Journal article, 2019-02-11)
      Background: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these ...