Browsing Bergen Open Research Archive by Author "Mathisen, Andreas Frøslev"
Now showing items 1-4 of 4
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Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors
Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne Bjørnson; Ræder, Helge; Chera, Simona (Journal article; Peer reviewed, 2021-04-02)The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms ... -
Demultiplexing Stress Responses and Compensatory Mechanisms in the Pancreatic Islet
Mathisen, Andreas Frøslev (Doctoral thesis, 2024-06-21)Et nøkkelelement i utviklingen av diabetes er den manglende evnen hos de insulinproduserende β-cellene til å møte et stigende behov for insulin, skapt av dysfunksjonelle eller døde β-celler. Det er mange faktorer som ... -
In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism
Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon; Vethe, Heidrun; Bjørlykke, Yngvild; Abadpour, Shadab; Paulo, Joao; Scholz, Hanne; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ... -
Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset
Mathisen, Andreas Frøslev; Vacaru, Andrei Mircea; Unger, Lucas; Lamba, Elena Mirela; Mardare, Oana-Ana-Maria; Daian, Laura Maria; Ghila, Luiza Mihaela; Vacaru, Ana-Maria; Chera, Simona (Journal article; Peer reviewed, 2024)Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint ...