Browsing Bergen Open Research Archive by Author "Mc Cormack, Emmet"

Now showing items 1-9 of 9

    • CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma 

      Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari; Popa, Mihaela Lucia; Akslen, Lars A.; Gjertsen, Bjørn Tore; Karlsen, Ida; Fosse, Vibeke Samuelsen; Bjørge, Line; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) ...

    • Combining Mass Cytometry Data by CyTOFmerge Reveals Additional Cell Phenotypes in the Heterogeneous Ovarian Cancer Tumor Microenvironment: A Pilot Study 

      Thomsen, Liv Cecilie Vestrheim; Kleinmanns, Katrin; Anandan, Shamundeeswari; Gullaksen, Stein-Erik; Abdelaal, Tamim; Iversen, Grete Alræk; Akslen, Lars Andreas; Mc Cormack, Emmet; Bjørge, Line (Journal article; Peer reviewed, 2023-10-23)
      The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and ...

    • Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16 

      Casey, Nicholas Paul; Kleinmanns, Katrin; Forcados, Christopher; Gelebart, Pascal Francois; Joaquina, Sandy; Lode, Martine Rott; Benard, Emmanuelle; Kaveh, Fatemeh; Caulier, Benjamin William; Gjerde, Christiane Helgestad; García de Jalón, Elvira; Warren, David; Lindemann, Kristina Yvonne Kathe; Rokkones, Erik; Davidson, Ben; Myhre, Marit; Kvalheim, Gunnar; Bjørge, Line; Mc Cormack, Emmet; Inderberg, Else Marit; Wälchli, Sébastien (Journal article; Peer reviewed, 2024)
      Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ...

    • Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells 

      Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik; Sundøy, Silje Maria; Gjertsen, Bjørn Tore; Kotopoulis, Spiros; Mc Cormack, Emmet (Peer reviewed; Journal article, 2019-07-06)
      Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ...

    • Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models. 

      Fonnes, Tina; Strand, Elin; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Espedal, Heidi; Sortland, Kristina; Stefansson, Ingunn; Bjørge, Line; Haldorsen, Ingfrid S.; Krakstad, Camilla; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ...

    • Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma 

      Hanes, Robert; Munthe, Else; Grad, Iwona; Han, Jianhua; Karlsen, Ida Tveit; Mc Cormack, Emmet; Meza-Zepeda, Leonardo A.; Stratford, Eva Wessel; Myklebost, Ola (Peer reviewed; Journal article, 2019-02-21)
      Background: FGFR inhibition has been proposed as treatment for dedifferentiated liposarcoma (DDLPS) with amplified FRS2, but we previously only demonstrated transient cytostatic effects when treating FRS2-amplified DDLPS ...

    • Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia 

      Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma; Stokowy, Tomasz; Hovland, Randi; Vaudel, Marc; Døskeland, Stein Ove; Mc Cormack, Emmet; Batth, Tanveer S; Olsen, Jesper V; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2020)
      Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ...

    • Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines ( 

      Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik; Ayuda-Duran, Maria del Pilar; Popa, Mihaela Lucia; Hovland, Randi; Brendehaug, Atle; Enserink, Jorrit; Mc Cormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)
      Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are proposed to be important for optimal therapy response. Tunneling ...

    • Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity 

      Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ...