Blar i Bergen Open Research Archive på forfatter "McCormack, Emmet"
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Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel; Sulen, Andre; Popa, Mihaela Lucia; Sørnes, Steinar; Reikvam, Håkon; Chan, Kok-Ping; Hovland, Randi; McCormack, Emmet; Bruserud, Øystein; Myers, Andrew G.; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-12-01)Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ... -
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors
McCormack, Emmet; Adams, Katherine J.; Hassan, Namir J.; Kotian, Akhil; Lissin, Nikolai M.; Sami, Malkit; Mujic, Maja; Osdal, Tereza; Gjertsen, Bjørn Tore; Baker, Deborah; Powlesland, Alex S.; Aleksic, Milos; Vuidepot, Annelise; Morteau, Olivier; Sutton, Deborah H.; June, Carl H.; Kalos, Michael; Ashfield, Rebecca; Jakobsen, Bent K. (Peer reviewed; Journal article, 2012-12)NY-ESO-1 and LAGE-1 are cancer testis antigens with an ideal profile for tumor immunotherapy, combining up-regulation in many cancer types with highly restricted expression in normal tissues and sharing a common HLA-A*0201 ... -
CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model
Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; de Jalón, Elvira Garcia; Tenstad, Olav; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ... -
Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model
García de Jalón, Elvira; Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; Bjørge, Line; Haug, Bengt Erik; McCormack, Emmet (Journal article; Peer reviewed, 2021)Purpose Fluorescence imaging (FLI) using targeted near-infrared (NIR) conjugates aids the detection of tumour lesions pre- and intraoperatively. The optimisation of tumour visualisation and contrast is essential and can ... -
Cross-Species Functional Genomic Analysis Identifies Resistance Genes of the Histone Deacetylase Inhibitor Valproic Acid
Forthun, Rakel Brendsdal; SenGupta, Tanima; Skjeldam, Hanne Kim; Lindvall, Jessica Margareta; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2012-11-14)The mechanisms of successful epigenetic reprogramming in cancer are not well characterized as they involve coordinated removal of repressive marks and deposition of activating marks by a large number of histone and DNA ... -
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Peer reviewed; Journal article, 2013)We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ... -
Development of a bioluminescent nitroreductase probe for preclinical imaging
Vorobyeva, Anzhelika G.; Stanton, Michael; Godinat, Aurélien; Lund, Kjetil B.; Karateev, Grigory G.; Francis, Kevin P.; Allen, Elizabeth; Gelovani, Juri G.; McCormack, Emmet; Tangney, Mark; Dubikovskaya, Elena A. (Peer reviewed; Journal article, 2015-06-25)Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In ... -
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
Zhang, Juan; Terán, Graciela; Popa, Mihaela-Lucia; Madapura, Harsha; Ladds, Marcus J.G.W.; Lianoudaki, Danai; Grünler, Jacob; Arsenian-Henriksson, Marie; McCormack, Emmet; Rottenberg, Martin Enrique; Catrina, Sergiu-Bogdan; Laín, Sonia; Darekar, Suhas (Journal article; Peer reviewed, 2021)Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer ... -
The emerging role of cd24 in cancer theranostics—a novel target for fluorescence image-guided surgery in ovarian cancer and beyond
Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)Complete cytoreductive surgery is the cornerstone of the treatment of epithelial ovarian cancer (EOC). The application of fluorescence image-guided surgery (FIGS) allows for the increased intraoperative visualization and ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Evaluating Translational Methods for Personalized Medicine—A Scoping Review
Fosse, Vibeke Samuelsen; Oldoni, Emanuela; Gerardi, Chiara; Banzi, Rita; Fratelli, Maddalena; Bietrix, Florence; Ussi, Anton; Andreu, Antonio L.; McCormack, Emmet (Journal article; Peer reviewed, 2022)The introduction of personalized medicine, through the increasing multi-omics characterization of disease, brings new challenges to disease modeling. The scope of this review was a broad evaluation of the relevance, validity, ... -
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma
Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten; Molven, Anders; Gjertsen, Bjørn Tore; Bjørge, Line; McCormack, Emmet (Peer reviewed; Journal article, 2014-03-04)Purpose: Preclinical models of epithelial ovarian cancer have not been exploited to evaluate the clinical standard combination therapy of surgical debulking with follow-up chemotherapy. As surgery is critical to patient ... -
The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer
Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina; Gjertsen, Bjørn Tore; McCormack, Emmet; Bjørge, Line (Peer reviewed; Journal article, 2016-06-28)Background: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the ... -
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ... -
Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia
Leitch, Calum; Osdal, Tereza; Andresen, Vibeke; Molland, Maren Kristine Butler; Kristiansen, Silje Elisabeth; Nguyen, Nhi Xuan; Bruserud, Øystein; Gjertsen, Bjørn Tore; McCormack, Emmet (Peer reviewed; Journal article, 2016)Palliative care in acute myeloid leukaemia (AML) is inadequate. For elderly patients, unfit for intensive chemotherapy, median survival is 2–3 months. As such, there is urgent demand for low-toxic palliative alternatives. ... -
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
Hofmann, Matthias; McCormack, Emmet; Mujic, Maja; Roßberg, Maila; Bernd, August; Bereiter-Hahn, Jürgen; Gjertsen, Bjørn Tore; Wiig, Helge; Kippenberger, Stefan (Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
Inhibiting notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ-secretase inhibitors
Mamaeva, Veronika; Niemi, Rasmus; Beck, Michaela; Özliseli, Ezgi; Desai, Diti; Landor, Sebastian; Grönroos, Tove J.; Kronqvist, Pauliina; Pettersen, Ina Katrine Nitschke; McCormack, Emmet; Rosenholm, Jessica M.; Linden, Mika; Sahlgren, Cecilia (Peer reviewed; Journal article, 2016-05)Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal of CSCs that display high glycolytic activity ... -
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Kamceva, Tina; Cros-Perrial, Emeline; Langer, Anika; de Garibay, Gorka Ruiz; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina (Journal article; Peer reviewed, 2020)Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ... -
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ... -
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ...