• Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder 

      de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Morken, Gunnar; Andreassen, Ole Andreas; Melle, Ingrid; Djurovic, Srdjan; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A.; Breen, Gerome (Peer reviewed; Journal article, 2018-10-08)
      Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the ...
    • Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis 

      Brandt, Christine Lycke; Doan, Nhat Trung; Tønnesen, Siren; Agartz, Ingrid; Hugdahl, Kenneth; Melle, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2015)
      Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural ...
    • Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders 

      Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas; Melle, Ingrid (Peer reviewed; Journal article, 2019-03-08)
      Objective: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in ...
    • Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. 

      Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Iversen, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas; Melle, Ingrid (Peer reviewed; Journal article, 2018-05-02)
      Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. ...
    • Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders 

      Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Peer reviewed, 2020)
      Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ...
    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
    • Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders 

      Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José; Flores, Susana Gil; Fabeiro, Francisco J. Cabaleiro; Noriega, Francisco del Río; Perez, Fermin Perez; González, Jesus Haro; Diaz, Guillermo Orozco; Diego-Otero, Yolanda de; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C.; Treutlein, Jens; Witt, Stephanie H.; Cichon, Sven; Kogevinas, Manolis; Bøen, Erlend; Dale, Anders M.; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Ødegaard, Ketil Joachim; Stordal, Eystein; Andreassen, Ole; Rivas, Fabio; Mayoral, Fermín; Müller-Myhsok, Bertram; Forstner, Andreas J.; Nöthen, Markus M.; Rietschel, Marcella; Stahl, Eli A.; Breen, Gerome; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Morken, Gunnar; Vaaler, Arne (Journal article; Peer reviewed, 2021)
      Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) ...
    • Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 

      van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article; Peer reviewed, 2022)
      Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...
    • Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes 

      van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik G.; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2018-10-02)
      The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ...
    • Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder 

      Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid; Bjella, Thomas; Aukrust, Pål; Le Hellard, Stephanie; Stavrum, Anne-Kristin; Melle, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)
      The complex effects of plant cannabinoids on human physiology is not yet fully understood, but include a wide spectrum of effects on immune modulation. The immune system and its inflammatory effector pathways are recently ...
    • Characterisation of age and polarity at onset in bipolar disorder 

      Kalman, Janos L.; Loohuis, Loes M. Olde; Vreeker, Annabel; McQuillin, Andrew; Stahl, Eli A.; Ruderfer, Douglas; Grigoroiu-Serbanescu, Maria; Panagiotaropoulou, Georgia; Ripke, Stephan; Bigdeli, Tim B.; Stein, Frederike; Meller, Tina; Meinert, Susanne; Pelin, Helena; Streit, Fabian; Papiol, Sergi; Adams, Mark J.; Adolfsson, Rolf; Adorjan, Kristina; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Anderson-Schmidt, Heike; Andreassen, Ole Andreas; Ardau, Raffaella; Aubry, Jean-Michel; Balaban, Ceylan; Djurovic, Srdjan; Lagerberg, Trine Vik; Melle, Ingrid; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean (Journal article; Peer reviewed, 2021)
      Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening ...
    • Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis 

      Ottesen, Akiah; Hegelstad, Wenche; Joa, Inge; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Johannessen, Jan Olav; Larsen, Tor Ketil; Haahr, Ulrik H.; McGlashan, T.H.; Friis, Svein; Melle, Ingrid (Journal article; Peer reviewed, 2021)
      Background: To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, ...
    • Common brain disorders are associated with heritable patterns of apparent aging of the brain 

      Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2019)
      Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ...
    • Composite immune marker scores associated with severe mental disorders and illness course 

      Ormerod, Monica Bettina E. Greenwood; Ueland, Thor; Werner, Maren Caroline Frogner; Hjell, Gabriela; Rødevand, Linn Nilsen; Sæther, Linn Sofie; Lunding, Synve Hoffart; Johansen, Ingrid Torp; Ueland, Torill; Lagerberg, Trine Vik; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have ...
    • Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors 

      Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey A; Andreassen, Ole; Melle, Ingrid; Morken, Gunnar; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ware, Erin B.; Stephan, Ripke; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fichter, Manfred M; Fernández-Aranda, Fernando; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stephane; Jimenez-Murcia, Susana; Johnson, Craig; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic ...
    • Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders 

      Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)
      The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...
    • Early identification of treatment non-response in first-episode psychosis 

      Wold, Kristin Fjelnseth; Ottesen, Akiah; Flaaten, Camilla Bärthel; Johnsen, Erik; Lagerberg, Trine Vik; Romm, Kristin Lie; Simonsen, Carmen; Ueland, Torill; Widing, Line Hustad; Åsbø, Gina; Melle, Ingrid (Journal article; Peer reviewed, 2023)
      Background Approximately one-third of patients with psychotic disorders does not respond to standard antipsychotic treatments. Consensus criteria for treatment resistance (TR) may aid the identification of non-response ...
    • Early substance use cessation improves cognition-10 years outcome in first-episode psychosis patients 

      Weibell, Melissa Anne E; Johannessen, Jan Olav; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Brønnick, Kolbjørn Kallesten; Haahr, Ulrik; Joa, Inge; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; Stain, Helen J.; Friis, Svein; Hegelstad, Wenche (Peer reviewed; Journal article, 2019-07-12)
      Background: Cognitive impairment may be a risk factor for, as well as a consequence of, psychosis. Non-remitting symptoms, premorbid functioning, level of education, and socioeconomic background are known correlates. A ...
    • Enrichment of genetic markers of recent human evolution in educational and cognitive traits 

      Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-08-22)
      Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing ...
    • An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD 

      Løkhammer, Solveig; Stavrum, Anne-Kristin Støbakk; Polushina, Tatiana; Aas, Monica; Ottesen, Akiah; Andreassen, Ole; Melle, Ingrid; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2022)
      Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and ...