Browsing Bergen Open Research Archive by Author "Mellgren, Gunnar"
Now showing items 1-20 of 62
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Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice
Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård; Haugen, Christine; Gudbrandsen, Oddrun Anita; Christensen, Anne Elisabeth; Rødahl, Eyvind; Fernø, Johan; Dankel, Simon N; Sagen, Jørn V.; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)Studies have implicated the extracellular matrix (ECM) of adipose tissue in insulin resistance. The proteoglycan decorin, a component of ECM, has been associated with glucose tolerance, but possible causal effects on ... -
The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells
Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N; Fenne, Ingvild Sveinsgjerd; Skartveit, Linn; Drangevåg, Andreas; Bozickovic, Olivera; Flågeng, Marianne Hauglid; Søiland, Håvard; Mellgren, Gunnar; Lien, Ernst Asbjørn (Peer reviewed; Journal article, 2015-04-13)Introduction: Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sumof tamoxifen and all itsmetabolites. 4-Hydroxytamoxifen ... -
Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial
DeCensi, Andrea; Johansson, Harriet; Helland, Thomas; Puntoni, Matteo; Macis, Debora; Aristarco, Valentina; Caviglia, Silvia; Webber, Tania Buttiron; Briata, Irene Maria; D’Amico, Mauro; Serrano, Davide; Guerrieri-Gonzaga, Aliana; Bifulco, Ersilia; Hustad, Simon Steinar; Søiland, Håvard; Boni, Luca; Bonanni, Bernardo; Mellgren, Gunnar (Journal article; Peer reviewed, 2021)Low-dose tamoxifen halves recurrence in non-invasive breast cancer without significant adverse events. Some adjuvant trials with tamoxifen 20 mg/day had shown an association between low endoxifen levels (9–16 nM) and ... -
Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer
Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar; Ekse, Dagfinn; Varhaug, Jan Erik; Mellgren, Gunnar; Steen, Vidar Martin; Lien, Ernst Asbjørn (Peer reviewed; Journal article, 2010-06-21)Background The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and ... -
Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.
Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind; McCann, Adrian; Bergseth, Marthe Tønder; Austgulen, Maren H.; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ... -
Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children
Ueland, Grethe Åstrøm; Kellmann, Ralf; Davidsen, Melissa Jørstad; Viste, Kristin; Husebye, Eystein Sverre; Almås, Bjørg; Storr, Helen L.; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Pétur Benedikt; Methlie, Paal (Journal article; Peer reviewed, 2021)Background Diagnosing Cushing syndrome (CS) can be challenging. The 24-hour urine free cortisol (UFC) measurement is considered gold standard. This is a laborious test, dependent on correct urine collection. Late-night ... -
Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study
Grytten, Elise; Laupsa-Borge, Johnny; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; Skorve, Jon; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Background & aims Marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower circulating levels of triacylglycerols (TAGs), and the plant-derived ... -
Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study
Våge, Villy; Sande, Vetle Aaberge; Mellgren, Gunnar; Laukeland, Camilla; Behme, Jan; Andersen, John Roger (Peer reviewed; Journal article, 2014-02-11)Background: To evaluate changes in obesity-related diseases and micronutrients after laparoscopic sleeve gastrectomy (LSG). Methods: We started the procedure in May 2007, and by December 2011, 117 patients could be evaluated ... -
COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1
Dankel, Simon N; Grytten, Elise; Bjune, Jan-Inge; Nielsen, Hans Jørgen; Dietrich, Arne; Blüher, Matthias; Sagen, Jørn V.; Mellgren, Gunnar (Journal article; Peer reviewed, 2020)Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a ... -
Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study
Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim; Midttun, Øivind; Ulvik, Arve; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2022)The transfer of one-carbon units between molecules in metabolic pathways is essential for maintaining cellular homeostasis, but little is known about whether the circulating concentrations of metabolites involved in the ... -
Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study
Vildmyren, Iselin Thowsen; Cao, Huy John Vu; Haug, Lina Bowitz; Valand, Ida Ulrikke; Eng, Øyvin Andre Solberg; Oterhals, Åge; Austgulen, Maren Hoff; Halstensen, Alfred; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita (Peer reviewed; Journal article, 2018-06-05)Improved process technologies have allowed fishing vessels to utilize residuals from cod fillet production (head, backbone, skin, cuttings, and entrails) and convert this to high-quality protein powders for human consumption. ... -
Dietary fish intake increased the concentration of soluble ACE2 in rats: can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?
O'Keeffe, Maria; Oterhals, Åge; Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mellgren, Gunnar; Halstensen, Alfred; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells after binding to the membrane-bound receptor angiotensin-converting enzyme 2 (ACE2), but this may be prevented through interception by soluble ... -
Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC)
Sommersten, Cathrine Horn; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen; Fasmer, Kristine Eldevik; Holmefjord, Mari-Anna Frydenlund; Revheim, Ingrid; Johannessen, Kristine Kjerpeseth; Næsheim, Nicole Tandrevold; Storås, Inghild; Leikanger, Trine; Amundsen, Kristin; Skjerve, Karoline Lyngstad; Lawrence-Archer, Laurence; Spjelkavik, Camilla; Haldorsen, Ingfrid S.; Lindseth, Inge Andreas; Dierkes, Jutta; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022)Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, ... -
Distinct T cell subsets in adipose tissue are associated with obesity
Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Sparrelid, Ernesto; Busch, Christian; Hjelmesæth, Jøran Sture; Hertel, Jens Kristoffer; Ponzetta, Andrea; Mellgren, Gunnar; Fernø, Johan; Björkström, Niklas K. (Journal article; Peer reviewed, 2022)Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data ... -
DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells
Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Mellgren, Gunnar; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07-09)DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases ... -
Efect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial
Helland, Anita; Bratlie, Marianne; Hagen, Ingrid V.; Midttun, Øivind; Sveier, Harald; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular ... -
Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites
Chen, Yuanhuang; Marcath, Lauren A.; Eliassen, Finn Magnus; Lende, Tone Hoel; Soiland, Havard; Mellgren, Gunnar; Helland, Thomas; Hertz, Daniel Louis (Journal article; Peer reviewed, 2021)Background: Tamoxifen, as a treatment of estrogen receptor positive (ER+) breast cancer, is a weak anti-estrogen that requires metabolic activation to form metabolites with higher anti-estrogenic activity. Endoxifen is the ... -
The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults
Schmedes, Mette; Balderas, Claudia; Aadland, Eli Kristin; Jacques, Hélène; Lavigne, Charles; Graff, Ingvild Eide; Eng, Øyvin Andre Solberg; Holthe, Asle; Mellgren, Gunnar; Young, Jette Feveile; Sundekilde, Ulrik Kræmer; Liaset, Bjørn; Bertram, Hanne Christine (Peer reviewed; Journal article, 2018-05-11)The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial ... -
Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats
Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder; Mjøs, Svein Are; Mola, Nazanin; Leh, Sabine Maria; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita (Peer reviewed; Journal article, 2017)Knowledge of the health impact of consuming heat-treated versus raw fish fillet is limited. To investigate effects of baked or raw salmon fillet intake on lipids and n-3 PUFAs in serum and tissues, obese Zucker fa/fa rats ... -
Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats
Gudbrandsen, Oddrun Anita; Kodama, Yosuke; Mjøs, Svein Are; Zhao, Chun-Mei; Johannesen, Helene; Brattbakk, Hans-Richard; Haugen, Christine; Kulseng, Bård Eirik; Mellgren, Gunnar; Chen, Duan (Peer reviewed; Journal article, 2014)Background: A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to ...