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Browsing Bergen Open Research Archive by Author "Melve, Guro Kristin"

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    • Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors 

      Hatfield, Kimberley Joanne; Melve, Guro Kristin; Bruserud, Øystein (Journal article; Peer reviewed, 2017)
      Introduction: Peripheral blood stem cells mobilized by granulocyte colony-stimulating factor (G-CSF) from healthy donors are commonly used for allogeneic stem cell transplantation. The effect of G-CSF administration on ...
    • Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses 

      Tvedt, Tor Henrik Anderson; Melve, Guro Kristin; Tsykunova, Galina; Ahmed, Aymen B; Brenner, Annette; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-22)
      Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ...
    • Immunomodulation induced by stem cell mobilization and harvesting in healthy donors: Increased systemic osteopontin levels after treatment with granulocyte colony-stimulating factor 

      Melve, Guro Kristin; Ersvær, Elisabeth; Akkøk, Cigdem Ahaein; Ahmed, Aymen B; Kristoffersen, Einar Klæboe; Hervig, Tor; Bruserud, Øystein (Peer reviewed; Journal article, 2016-07-19)
      Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. The frequency of severe ...
    • Immunoregulatory networks in healthy adult allogeneic stem cell donors : Studies of peripheral hematopoietic stem cell donors and their recipients 

      Melve, Guro Kristin (Doctoral thesis, 2020-10-28)
      Final outcome after allogeneic peripheral blood stem cell transplantation (PBSCT) is influenced by the high degrees of variation in disease and comorbidities among recipients, as well as the pre-and post-transplant handling ...
    • Peripheral blood stem cell mobilization in healthy Donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets 

      Melve, Guro Kristin; Ersvær, Elisabeth; Eide, Geir Egil; Kristoffersen, Einar Klæboe; Bruserud, Øystein (Peer reviewed; Journal article, 2018-05-02)
      Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible ...

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