Blar i Bergen Open Research Archive på forfatter "Metra, Marco"

Viser treff 1-20 av 22

    • Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction 

      Savarese, Gianluigi; Uijl, Alicia; Ouwerkerk, Wouter; Tromp, Jasper; Anker, Stefan D.; Dickstein, Kenneth; Hage, Camilla; Lam, Carolyn S.P.; Lang, Chim C.; Metra, Marco; Ng, Leong L.; Orsini, Nicola; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Cleland, John G.F.; Voors, Adriaan A.; Lund, Lars H. (Journal article; Peer reviewed, 2022)
      Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ...

    • Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome 

      van der Hoef, Camilla C.S.; Boorsma, Eva M.; Emmens, Johanna E.; van Essen, Bart J.; Metra, Marco; Ng, Leong L.; Anker, Stefan D.; Dickstein, Kenneth; Mordi, Ify R.; Dihoum, Adel; Lang, Chim C.; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2023)
      Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ...

    • Clinical and prognostic associations of autoantibodies recognizing adrenergic/muscarinic receptors in patients with heart failure 

      Markousis-Mavrogenis, George; Minich, Waldemar B.; Al-Mubarak, Ali A.; Anker, Stefan D.; Cleland, John G. F.; dickstein, kenneth; Lang, Chim C.; Ng, Leong L.; Samani, Nilesh J.; Zannad, Faiez; Metra, Marco; Seemann, Petra; Hoeg, Antonia; Lopez, Patricio; Van Veldhuisen, Dirk J.; De Boer, Rudolf A.; Voors, Adriaan A.; Van Der Meer, Peter; Schomburg, Lutz; Bomer, Nils (Journal article; Peer reviewed, 2023)
      Aims The importance of autoantibodies (AABs) against adrenergic/muscarinic receptors in heart failure (HF) is not well-understood. We investigated the prevalence and clinical/prognostic associations of four AABs recognizing ...

    • Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Inciardi, Riccardo M.; Lang, Chim C.; Lombardi, Carlo; Ng, Leong L.; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Background: Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR ...

    • Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure 

      Inciardi, Riccardo M.; Pagnesi, Matteo; Lombardi, Carlo M.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Pellicori, Pierpaolo; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Solomon, Scott D.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Aims Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization ...

    • Clinical implications of low estimated protein intake in patients with heart failure 

      Streng, Koen W.; Hillege, Hans L.; ter Maaten, Jozine M.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Ng, Leong L.; Samani, Nilesh J.; Metra, Marco; Ponikowski, Piotr; Cleland, John G.; Anker, Stefan D.; Romaine, Simon P.R.; Damman, Kevin; van der Meer, Peter; Lang, Chim C.; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)
      Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are ...

    • Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure 

      Boorsma, Eva M.; ter Maaten, Jozine M.; Damman, Kevin; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Santos, Karine; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Ravera, Alice; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2021)
      Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy ...

    • Impaired high-density lipoprotein function in patients with heart failure 

      Emmens, Johanna E.; Jia, Congzhuo; Ng, Leong L.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Lang, Chim C.; Filippatos, Gerasimos; Cleland, John G.; Metra, Marco; Voors, Adriaan A.; de Boer, Rudolf A.; Tietge, Uwe J. F. (Journal article; Peer reviewed, 2021)
      Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, ...

    • Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF 

      Markousis-Mavrogenis, George; Tromp, Jasper; Ouwerkerk, Wouter; Ferreira, João Pedro; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Lang, Chim C; Metra, Marco; Samani, Nilesh J; De Boer, Rudolf A; Van Veldhuisen, Dirk J; Voors, Adriaan A; Van Der Meer, Peter (Journal article; Peer reviewed, 2022)
      Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ...

    • Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction 

      Curran, Fraser M.; Bhalraam, U.; Mohan, Mohapradeep; Singh, Jagdeep S.; Anker, Stefan D.; Dickstein, Kenneth; Doney, Alexander S.; Filippatos, Gerasimos; George, Jacob; Metra, Marco; Ng, Leong L.; Palmer, Colin N.; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Lang, Chim C.; Mordi, Ify R. (Journal article; Peer reviewed, 2021)
      Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil-to-lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation. Its relationship with other inflammatory ...

    • Old and new equations for maximal heart rate prediction in patients with heart failure and reduced ejection fraction on beta-blockers treatment: results from the MECKI score data set 

      Magrì, Damiano; Piepoli, Massimo; Gallo, Giovanna; Corrà, Ugo; Metra, Marco; Paolillo, Stefania; Filardi, Pasquale Perrone; Maruotti, Antonello; Salvioni, Elisabetta; Mapelli, Massimo; Vignati, Carlo; Senni, Michele; Limongelli, Giuseppe; Lagioia, Rocco; Scrutinio, Domenico; Emdin, Michele; Passino, Claudio; Parati, Gianfranco; Sinagra, Gianfranco; Correale, Michele; Badagliacca, Roberto; Sciomer, Susanna; Di Lenarda, Andrea; Agostoni, Piergiuseppe (Journal article; Peer reviewed, 2022)
      Aims Predicting maximal heart rate (MHR) in heart failure with reduced ejection fraction (HFrEF) still remains a major concern. In such a context, the Keteyian equation is the only one derived in a HFrEF cohort on optimized ...

    • Pathophysiological pathways in patients with heart failure and atrial fibrillation 

      Santema, Bernadet T.; Arita, Vicente Artola; Sama, Iziah E.; Kloosterman, Mariëlle; van den Berg, Maarten P.; Nienhuis, Hans L.A.; Van Gelder, Isabelle C.; van der Meer, Peter; Zannad, Faiez; Metra, Marco; Ter Maaten, Jozine M.; Cleland, John G.; Ng, Leong L.; Anker, Stefan D.; Lang, Chim C.; Samani, Nilesh J.; Dickstein, Kenneth; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Rienstra, Michiel; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)
      Aims Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into the underlying pathophysiological pathways in HF patients with AF by comparing ...

    • Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure 

      Ceelen, Daan; Voors, Adriaan A.; Tromp, Jasper; van Veldhuisen, Dirk J.; Dickstein, Kenneth; de Boer, Rudolf A.; Lang, Chim C.; Anker, Stefan D.; Ng, Leong L.; Metra, Marco; Ponikowski, Piotr; Figarska, Sylwia M. (Journal article; Peer reviewed, 2022)
      Aims Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 ...

    • Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure 

      Kobayashi, Masatake; Voors, Adriaan A.; Ouwerkerk, Wouter; Duarte, Kevin; Girerd, Nicolas; Rossignol, Patrick; Metra, Marco; Lang, Chim C.; Ng, Leong L.; Filippatos, Gerasimos; Dickstein, Kenneth; van Veldhuisen, Dirk J.; Zannad, Faiez; Ferreira, João Pedro (Journal article; Peer reviewed, 2021)
      Background Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In ...

    • Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire 

      Ravera, Alice; Santema, Bernadet T.; Sama, Iziah E.; Meyer, Sven; Lombardi, Carlo; Carubelli, Valentina; Ferreira, João Pedro; Lang, Chim C.; Dickstein, Kenneth; Anker, Stefan D.; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Teerlink, John R.; Metra, Marco; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ-5D), and to ...

    • Repetitive use of levosimendan for treatment of chronic advanced heart failure: Clinical evidence, practical considerations, and perspectives: An expert panel consensus 

      Nieminen, Markku Sakari; Altenberger, Johann; Ben-Gal, Tuvia; Böhmer, Armin; Comin-Colet, Josep; Dickstein, Kenneth; Édes, István Ferenc; Fedele, Francesco; Fonseca, Cândida; García-González, Martín J.; Giannakoulas, Georgios A.; Iakobishvili, Zaza; Jääskeläinen, Pertti; Karavidas, Apostolos I.; Kettner, Jiří; Kivikko, Matti; Lund, Lars H.; Matskeplishvili, Simon T.; Metra, Marco; Morandi, Fabrizio; Oliva, Fabrízio A.; Parkhomenko, Alexander; Parissis, John T.; Pollesello, Piero; Pölzl, Gerhard; Schwinger, Robert H.G.; Segovia, Javier; Seidel, Monika; Vrtovec, Bojan; Wikström, Gerhard (Peer reviewed; Journal article, 2014-06-15)
      Background The intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In the last decade scientific and clinical interest has arisen for its repetitive or ...

    • Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease 

      Weening, Eerde H.; Al-Mubarak, Ali A.; Dokter, Martin M.; Dickstein, Kenneth; Lang, Chim C.; Ng, Leong L.; Metra, Marco; van Veldhuisen, Dirk J.; Touw, Daan J.; de Boer, Rudolf A.; Gansevoort, Ron T.; Voors, Adriaan A.; Bakker, Stephan J. L.; van der Meer, Peter; Bomer, Nils (Journal article; Peer reviewed, 2023)
      Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food ...

    • Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure 

      de Koning, Marie-Sophie L. Y.; Emmens, Johanna E.; Romero-Hernández, Esteban; Bourgonje, Arno R.; Assa, Solmaz; Figarska, Sylwia M.; Cleland, John G. F.; Samani, Nilesh J.; Ng, Leong L.; Lang, Chim C.; Metra, Marco; Filippatos, Gerasimos S.; van Veldhuisen, Dirk J.; Anker, Stefan D.; Dickstein, Kenneth; Voors, Adriaan A.; Lipsic, Erik; van Goor, Harry; van der Harst, Pim (Journal article; Peer reviewed, 2023)
      Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ...