• CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup 

      Aasebø, Kristine; Dragomir, Anca; Sundström, Magnus; Mezheyeuski, Artur; Edqvist, Per-Henrik; Eide, Geir Egil; Pontén, Fredrik; Pfeiffer, Per; Glimelius, Bengt; Sorbye, Halfdan (Journal article; Peer reviewed, 2020-02-11)
      Background: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type ...
    • Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients 

      Aasebø, Kristine; Dragomir, Anca; Sundström, Magnus; Mezheyeuski, Artur; Edqvist, Per-Henrik; Eide, Geir Egil; Pontén, Fredrik; Pfeiffer, Per; Glimelius, Bengt; Sorbye, Halfdan (Peer reviewed; Journal article, 2019-05-09)
      Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the ...
    • Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis 

      Nunes, Luís; Aasebø, Kristine; Mathot, Lucy; Ljungström, Viktor; Edqvist, Per-Henrik; Sundström, Magnus; Dragomir, Anca; Pfeiffer, Per; Ameur, Adam; Pontén, Fredrik; Mezheyeuski, Artur; Sorbye, Halfdan; Sjöblom, Tobias; Glimelius, Bengt (Journal article; Peer reviewed, 2020-01-10)
      Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ...
    • Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer 

      Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S.M.; Elfving, Hedvig; Brunnström, Hans; O'Reilly, Aine; Bosic, Martina; Gulyas, Miklos; Isaksson, Johan; Botling, Johan; Kärre, Klas; Jirström, Karin; Lamberg, Kristina; Pontén, Fredrik; Leandersson, Karin; Mezheyeuski, Artur; Micke, Patrick (Journal article; Peer reviewed, 2023)
      Introduction: Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune phenotypes in the mutational and clinicopathological ...
    • Vessel size as a marker of survival in estrogen receptor positive breast cancer 

      Milosevic, Vladan; Edelmann, Reidunn Jetne; Winge, Ingeborg; Strell, Carina; Mezheyeuski, Artur; Knutsvik, Gøril; Askeland, Cecilie; Wik, Elisabeth; Akslen, Lars Andreas; Östman, Arne (Journal article; Peer reviewed, 2023)
      Purpose: Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and perivascular a-SMA expression as prognostic biomarkers in ...