Browsing Bergen Open Research Archive by Author "Michoel, Tom Luk Robert"

Now showing items 1-5 of 5

    • Changes in the gene expression profile during spontaneous migraine attacks 

      Kogelman, Lisette J.A.; Falkenberg, Katrine; Buil, Alfonso; Erola, Pau; Courraud, Julie; Laursen, Susan Svane; Michoel, Tom Luk Robert; Olesen, Jes; Hansen, Thomas F. (Journal article; Peer reviewed, 2021)
      Migraine attacks are delimited, allowing investigation of changes during and outside attack. Gene expression fluctuates according to environmental and endogenous events and therefore, we hypothesized that changes in RNA ...

    • Comparison between instrumental variable and mediation-based methods for reconstructing causal gene networks in yeast 

      Ludl, Adriaan-Alexander; Michoel, Tom Luk Robert (Journal article; Peer reviewed, 2021)
      Causal gene networks model the flow of information within a cell. Reconstructing causal networks from omics data is challenging because correlation does not imply causation. When genomics and transcriptomics data from a ...

    • High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering 

      Wang, Lingfei; Audenaert, Pieter; Michoel, Tom Luk Robert (Journal article; Peer reviewed, 2019)
      Studying the impact of genetic variation on gene regulatory networks is essential to understand the biological mechanisms by which genetic variation causes variation in phenotypes. Bayesian networks provide an elegant ...

    • Model-based clustering of multi-tissue gene expression data 

      Erola, Pau; Björkegren, Johan L.M.; Michoel, Tom Luk Robert (Journal article; Peer reviewed, 2020)
      Motivation Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from dozens to hundreds of individuals. ...

    • Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease 

      Crawford, Andrew A.; Bankier, Sean; Altmaier, Elisabeth; Barnes, Catriona L. K.; Clark, David W.; Ermel, Raili; Friedrich, Nele; van der Harst, Pim; Joshi, Peter K.; Karhunen, Ville; Lahti, Jari; Mahajan, Anubha; Mangino, Massimo; Nethander, Maria; Neumann, Alexander; Pietzner, Maik; Sukhavasi, Katyayani; Wang, Carol A.; Bakker, Stephan J. L.; Bjorkegren, Johan L. M.; Campbell, Harry; Eriksson, Johan G.; Gieger, Christian; Hayward, Caroline; Jarvelin, Marjo-Riitta; McLachlan, Stela; Morris, Andrew P.; Ohlsson, Claes; Pennell, Craig E.; Price, Jackie; Rudan, Igor; Ruusalepp, Arno; Spector, Tim; Tiemeier, Henning; Völzke, Henry; Wilson, James F.; Michoel, Tom Luk Robert; Timpson, Nicolas J.; Smith, George Davey; Walker, Brian R. (Journal article; Peer reviewed, 2021)
      The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ...