Blar i Bergen Open Research Archive på forfatter "Molès, Jean-Pierre"
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Clinical and Biological Factors Associated with Early Epstein-Barr Virus Infection in Human Immunodeficiency Virus-Exposed Uninfected Infants in Eastern Uganda
Montoya-Ferrer, Ana; Sanosyan, Armen; Fayd'Herbe De Maudave, Alexis; Pisoni, Amandine; Bollore, Karine; Molès, Jean-Pierre; Peries, Marianne; Tylleskär, Thorkild; Tumwine, James K.; Ndeezi, Grace; Gorgolas, Miguel; Nagot, Nicolas; Van De Perre, Philippe; Tuaillon, Edouard (Journal article; Peer reviewed, 2021)Background Immune control of Epstein-Barr virus (EBV) infection is impaired in individuals with HIV. We explored maternal factors associated with EBV acquisition in HIV-exposed uninfected (HEU) infants and the relationship ... -
Design and challenges of a large HIV prevention clinical study on mother-to-child transmission: ANRS 12397 PROMISE-EPI study in Zambia and Burkina Faso
Mennecier, Anaïs; Kankasa, Chipepo; Fao, Paulin; Molès, Jean-Pierre; Eymard-Duvernay, Sabrina; Mwiya, Mwiya; Kania, Dramane; Chunda-Liyoka, Catherine; Sakana, Leticia; Rutagwera, David; Tassembedo, Souleymane; Wilfred-Tonga, Maria Melany; Mosqueira, Beatriz; Tylleskär, Thorkild; Nagot, Nicolas; Van De Perre, Philippe (Journal article; Peer reviewed, 2021)Post-natal HIV infection through breastfeeding remains a challenge in many low and middle-income countries, particularly due to non-availability of alternative infant feeding options and the suboptimal Prevention of Mother ... -
Eliminating HIV transmission through breast milk from women taking antiretroviral drugs
Goga, Ameena; Van de Perre, Philippe; Ngandu, Nobubelo; Nagot, Nicolas; Abrams, Elaine J; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Sherman, Gayle G; Pillay, Yogan; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021) -
Eliminating postnatal HIV transmission in high incidence areas: need for complementary biomedical interventions
Van de Perre, Philippe; Goga, Ameena; Ngandu, Nobubelo; Nagot, Nicolas; Moodley, Dhayendre; King, Rachel; Molès, Jean-Pierre; Mosqueira, Beatriz; Chirinda, Witness; Scarlatti, Gabriella; Tylleskär, Thorkild; Dabis, François; Gray, Glenda (Journal article; Peer reviewed, 2021)The rate of mother-to-child transmission (MTCT) of HIV from breastfeeding is increasing relative to other causes of MTCT. Early effective preconception and antenatal antiretroviral therapy (ART) reduces intrauterine and ... -
Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1‑year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life
Nagot, Nicolas; Singata-Madliki, Mandisa; Cournil, Amandine; Nalugya, Joyce; Tassembedo, Soleymane; Quillet, Catherine; Tonga, Melany W.; Tumwine, James K; Meda, Nicolas; Kankasa, Chipepo; Mwiya, Mwiya; Bangirana, Paul; Peries, Marianne; Batting, Joanne; Engebretsen, Ingunn Marie Stadskleiv; Tylleskär, Thorkild; Van de Perre, Philippe; Ndeezi, Grace; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)In the ANRS 12174 trial, HIV-exposed uninfected African neonates who received lopinavir-ritonavir (LPV/r) prophylaxis for 1 year exhibited slower growth from birth to week 50 compared with those receiving lamivudine (3TC). ... -
Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis
Monnin, Audrey; Vizeneux, Amélie; Nagot, Nicolas; Eymard-Duvernay, Sabrina; Meda, Nicolas; Singata-Madliki, Mandisa; Ndeezi, Grace; Tumwine, James K; Kankasa, Chipepo; Goga, Ameena; Tylleskär, Thorkild; Van de Perre, Philippe; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of ... -
Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns
Monnin, Audrey; Desquiret-Dumas, Valérie; Meda, Nicolas; Goudenège, David; Bris, Céline; Kankasa, Chipepo; Singata-Madliki, Mandisa; Tylleskär, Thorkild; Procaccio, Vincent; Nagot, Nicolas; Van De Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)Worldwide, one million HIV-exposed uninfected (HEU) children are born yearly, and chronic health impairments have been reported in these children. Mitochondrial DNA (mtDNA) instability and altered mtDNA content have been ... -
Prevalence and determinants of HIV shedding in breast milk during continued breastfeeding among Zambian mothers not on antiretroviral treatment (ART): A cross-sectional study
Rutagwera, David Gatsinzi; Molès, Jean-Pierre; Kankasa, Chipepo; Mwiya, Mwiya; Tuaillon, Edouard; Peries, Marianne; Nagot, Nicolas; Van de Perre, Philippe; Tylleskär, Thorkild (Peer reviewed; Journal article, 2019)The risk of postnatal HIV transmission exists throughout the breastfeeding period. HIV shedding in breast milk beyond six months has not been studied extensively. The aim of this study was to determine prevalence and ...