• Long-term persistence of mitochondrial DNA instability in HIV-exposed uninfected children during and after exposure to antiretroviral drugs and HIV 

      Desquiret-Dumas, Valérie; D’Ottavi, Morgana; Monnin, Audrey; Goudenège, David; Méda, Nicolas; Vizeneux, Amélie; Kankasa, Chipepo; Tylleskär, Thorkild; Bris, Céline; Procaccio, Vincent; Nagot, Nicolas; Van de Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2022)
      HIV-exposed uninfected (HEU) children show impaired health outcomes during childhood. A high rate of mitochondrial DNA (mtDNA) instability was reported in the blood of HEU at birth. We aimed to explore the relationship ...
    • Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as Prophylaxis 

      Monnin, Audrey; Vizeneux, Amélie; Nagot, Nicolas; Eymard-Duvernay, Sabrina; Meda, Nicolas; Singata-Madliki, Mandisa; Ndeezi, Grace; Tumwine, James K; Kankasa, Chipepo; Goga, Ameena; Tylleskär, Thorkild; Van de Perre, Philippe; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Telomere shortening can be enhanced upon human immunodeficiency virus (HIV) infection and by antiretroviral (ARV) exposures. The aim of this study was to evaluate the acute and long-term effect on telomere shortening of ...
    • Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns 

      Monnin, Audrey; Desquiret-Dumas, Valérie; Meda, Nicolas; Goudenège, David; Bris, Céline; Kankasa, Chipepo; Singata-Madliki, Mandisa; Tylleskär, Thorkild; Procaccio, Vincent; Nagot, Nicolas; Van De Perre, Philippe; Reynier, Pascal; Molès, Jean-Pierre (Journal article; Peer reviewed, 2021)
      Worldwide, one million HIV-exposed uninfected (HEU) children are born yearly, and chronic health impairments have been reported in these children. Mitochondrial DNA (mtDNA) instability and altered mtDNA content have been ...