Browsing Bergen Open Research Archive by Author "Mostafavi, Sepideh"
Now showing items 1-5 of 5
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Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations
Liang, Xiao; Kristiansen, Cecilie Katrin; Mostafavi, Sepideh; Vatne, Guro H.; Zantingh, Gina; Kianian, Atefeh; Tzoulis, Charalampos; Høyland, Lena Elise; Ziegler, Mathias; Perez, Roberto Megias; Furriol, Jessica; Zhang, Zhuoyuan; Balafkan, Novin; Hong, Yu; Siller, Richard; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using ... -
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
Mostafavi, Sepideh; Balafkan, Novin; Pettersen, Ina Katrine Nitschke; Nido, Gonzalo Sanchez; Siller, Richard; Tzoulis, Charalampos; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2021-10-14)Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ... -
Metagenome-based analysis of the functional potential of a marine sediment community dominated by ANME-2c
Mostafavi, Sepideh (Master thesis, 2015-10-26)Methane is the most abundant hydrocarbon in the atmosphere and after CO2; it contributes for 14% of global greenhouse gas emissions. Marine sediments are a large reservoir of methane where approximately 80% of the methane ... -
A method for dierentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96‐well microplates
Balafkan, Novin; Mostafavi, Sepideh; Schubert, Manja; Siller, Richard; Liang, Xiao; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards cardiomyocytes ... -
Using induced pluripotent stem cells for modeling POLG mitochondrial disease : Stamceller som modellsystem for å behandle mitokondriesykdom
Mostafavi, Sepideh (Doctoral thesis, 2022-02-03)Background: More than 90% of the energy required to sustain life is provided by mitochondria through the process of oxidative phosphorylation (OXPHOS). The role of mitochondria, however, is not restricted to supplying ...