Blar i Bergen Open Research Archive på forfatter "Mustafa, Kamal Babikeir Eln"
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Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells cultured in 3D Copolymer Scaffolds Enhances Bone Formation
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Bruland, Ove; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-01-25)Selection of appropriate osteoinductive growth factors, suitable delivery method and proper supportive scaffold are critical for a successful outcome in bone tissue engineering using bone marrow stromal cells (BMSC). This ... -
Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect
Sharma, Sunita; Xue, Ying; Xing, Zhe; Yassin, Mohammed Ahmed; Sun, Yang; Lorens, James; Finne-Wistrand, Anna; Sapkota, Dipak; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-04-11)Apart from osteogenesis, neovascularization of the defect area is an important determinant for successful bone healing. Accordingly, several studies have employed the combined delivery of VEGFA and BMP2 for bone regeneration. ... -
Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison
Mohamed-Ahmed, Samih; Fristad, Inge; Lie, Stein Atle; Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Vindenes, Hallvard; Idris, Shaza Bushra M. (Journal article; Peer reviewed, 2018-06)Background Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different studies comparing ASCs and BMSCs have shown ... -
Altered surface hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells
Xing, Zhe; Cai, Jiazheng; Sun, Yang; Cao, Mengnan; Li, Yi; Xue, Ying; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) (or poly(LLA-co-CL)) porous scaffolds are good candidates for use as ... -
Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells
Bartaula-Brevik, Sushma; Pedersen, Torbjørn Østvik; Finne-Wistrand, Anna; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-02)It has been suggested that the effect of implanted cells on the local environment is important when selecting the appropriate cell type for tissue regeneration. Our aim was to compare the local tissue response to implanted ... -
Association between Oral Health Status and Type 2 Diabetes Mellitus among Sudanese Adults: A Matched Case-Control Study
Mohamed, Hasaan Gassim; Idris, Shaza Bushra; Ahmed, Mutaz Faisal; Bøe, Olav Egil; Mustafa, Kamal Babikeir Eln; Ibrahim, Salah Osman; Åstrøm, Anne Nordrehaug (Peer reviewed; Journal article, 2013-12-11)Aim: The purpose of this study was to compare the clinical and subjective oral health indicators of type 2 diabetic patients (T2DM) with age and gender matched non-diabetic controls. A second aim was to identify clinical ... -
Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin
Omer, A; Al-sharabi, Niyaz Abdulbaqi; Qiu, Y; Li, Y; Fujio, Masahito; Mustafa, Kamal Babikeir Eln; Xing, Zhe (Journal article; Peer reviewed, 2020)Collagen 1 (COL1) and fibronectin (FN) are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp cells (DPCs). The purpose of this study was to investigate the effect of COL1 ... -
Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration
Yassin, Mohammed Ahmed; Leknes, Knut N.; Pedersen, Torbjørn Østvik; Xing, Zhe; Sun, Yang; Lie, Stein Atle; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-11)Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. Therefore, the objective of this study was to determine the effect of bone marrow stromal stem cells (BMSCs) density ... -
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial
Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Hellem, Sølve; Rojewski, Markus; Gjengedal, Harald; Yassin, Mohammed Ahmed Alamin Yousif; Feng, Xin; Skaale, Siren G; Berge, Trond Inge; Rosén, Annika; Shi, Xieqi; Ahmed, Aymen B; Gjertsen, Bjørn Tore; Schrezenmeier, Hubert; Layrolle, Pierre (Journal article; Peer reviewed, 2018)Background Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone ... -
Comparison of bone regenerative capacity of donor-matched human adipose–derived and bone marrow mesenchymal stem cells
Mohamed Ahmed, Samih; Yassin, Mohammed Ahmed; Elsebahy, Ahmad Rashad Saad Mohamed; Espedal, Heidi; Idris, Shaza Bushra M.; Finne-Wistrand, Anna; Vindenes, Hallvard; Mustafa, Kamal Babikeir Eln; Fristad, Inge (Journal article; Peer reviewed, 2020-11)Adipose-derived stem cells (ASC) have been used as an alternative to bone marrow mesenchymal stem cells (BMSC) for bone tissue engineering. However, the efficacy of ASC in bone regeneration in comparison with BMSC remains ... -
Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Rajthala, Saroj; Yassin, Mohammed Ahmed Alamin Yousif; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2018-01-31)Background: In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence ... -
The effect of hydroxyapatite nanocrystals on osseointegration of titanium implants: an in vivo rabbit study
Breding, Karin; Jimbo, Ryo; Hayashi, Mariko; Xue, Ying; Mustafa, Kamal Babikeir Eln; Andersson, Martin (Peer reviewed; Journal article, 2014-01-19)Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they ... -
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration
Munir, Arooj; Døskeland, Anne; Avery, Steven J; Fuoco, Tiziana; Mohamed Ahmed, Samih; Lygre, Henning; Finne-Wistrand, Anna; Sloan, Alastair J; Waddington, Rachel J; Mustafa, Kamal Babikeir Eln; Suliman, Salwa (Journal article; Peer reviewed, 2019)Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after ... -
Endothelial cells influence the osteogenic potential of bone marrow stromal cells
Xue, Ying; Xing, Zhe; Hellem, Sølve; Arvidson, Kristina Fyrberg; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2009-11-17)Background: Improved understanding of the interactions between bone cells and endothelial cells involved in osteogenesis should aid the development of new strategies for bone tissue engineering. The aim of the present study ... -
Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs
Pedersen, Torbjørn Østvik; Blois, Anna L; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James B.; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2013-05-17)Introduction: A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic ... -
Engineering 3D degradable, pliable scaffolds toward adipose tissue regeneration; optimized printability, simulations and surface modification
Jain, Shubham; Yassin, Mohammed Ahmed; Fuoco, Tiziana; Liu, Hailong; Mohamed Ahmed, Samih; Mustafa, Kamal Babikeir Eln; Finne-Wistrand, Anna (Journal article; Peer reviewed, 2020)We present a solution to regenerate adipose tissue using degradable, soft, pliable 3D-printed scaffolds made of a medical-grade copolymer coated with polydopamine. The problem today is that while printing, the medical grade ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Impact of chronic periodontitis on levels of glucoregulatory biomarkers in gingival crevicular fluid of adults with and without type 2 diabetes
Mohamed, Hasaan Gassim; Idris, Shaza Bushra; Mustafa, Manal; Ahmed, Mutaz F.; Åstrøm, Anne Nordrehaug; Mustafa, Kamal Babikeir Eln; Ibrahim, Salah Osman (Peer reviewed; Journal article, 2015-05-20)The relationship between diabetes and periodontal disease is bidirectional, but information about the effect of chronic periodontitis on the levels of the glucoregulatory biomarkers locally in gingival crevicular fluid ... -
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells
Suliman, Salwa; Ali, Hassan Mohamed Abdel-Raouf; Karlsen, Tommy Aleksander; Amiaud, Jérôme; Mohamed Ahmed, Samih; Layrolle, Pierre; Costea, Daniela Elena; Brinchmann, Jan E.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-11-05)Therapeutic potential of human bone marrow stromal/stem cells (hBMSC) must be developed using well defined xenogenic-free conditions. hBMSC were isolated from healthy donors (n = 3) using different isolation and expansion ... -
In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2
Suliman, Salwa; Sun, Yang; Pedersen, Torbjørn Østvik; Xue, Ying; Nickel, Joachim; Waag, Thilo; Finne-Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Costea, Daniela Elena; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-03)The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(ε-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response and degradation. The ...