Blar i Bergen Open Research Archive på forfatter "Mydel, Piotr Mateusz"

Viser treff 1-15 av 15

    • Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans 

      Nepal, Chirag; Taranta, Andrzej; Hadzhiev, Yavor; Pundhir, Sachin; Mydel, Piotr Mateusz; Lenhard, Boris; Müller, Ferenc; Andersen, Jesper B. (Journal article; Peer reviewed, 2020-04)
      HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ...

    • AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model 

      Chen, Tony Jialiang; Mydel, Piotr Mateusz; Benedyk-Machaczka, Małgorzata; Kamińska, Marta; Kalucka, Urszula; Blø, Magnus; Furriol, Jessica; Gausdal, Gro; Lorens, James Bradley; Osman, Tarig Al-Hadi; Marti, Hans Peter (Journal article; Peer reviewed, 2021)
      AXL tyrosine kinase activation enhances cancer cell survival, migration, invasiveness, and promotes drug resistance. AXL overexpression is typically detected in a high percentage of renal cell carcinomas (RCCs) and is ...

    • Carbamylation of immunoglobulin abrogates activation of the classical complement pathway 

      Koro, Catalin; Bielecka, Ewa; Dahl-Knudsen, Anders; Enghild, Jan J; Scavenius, Carsten; Brun, Johan G; Binder, Veronika; Hellvard, Annelie; Bergum, Brith; Jonsson, Roland; Potempa, Jan; Blom, Anna M.; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2014-11)
      Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory ...

    • Development of a novel, high-affinity ssDNA trypsin inhibitor 

      Malicki, Stanislaw; Ksiazek, Miroslaw; Majewski, Pawel; Pecak, Aleksandra; Mydel, Piotr Mateusz; Grudnik, Przemyslaw; Dubin, Grzegorz (Peer reviewed; Journal article, 2019)
      Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we ...

    • Development of selective ssDNA micro-probe for PD1 detection as a novel strategy for cancer imaging 

      Malicki, Stanisław; Czarna, Anna; Żyła, Edyta; Pucelik, Barbara; Gałan, Wojciech; Chruścicka, Barbara; Kaminska, Marta; Sochaj-Gregorczyk, Alicja; Magiera-Mularz, Katarzyna; Wang, Jun; Winiarski, Marek; Benedyk-Machaczka, Małgorzata; Kozieł, Joanna; Dubin, Grzegorz; Mydel, Piotr Mateusz (Journal article; Peer reviewed, 2024)
      Programmed death receptor 1, PD1, modulates the function of immune cells by providing inhibitory signals and constitutes the marker of immune exhaustion. Monitoring the level of PD1 promises a useful diagnostic approach ...

    • Discovery of novel potential reversible peptidyl arginine deiminase inhibitor 

      Aliko, Ardita; Kaminska, Marta; Falkowski, Katherine; Bielecka, Ewa; Benedyk-Machaczka, Malgorzata; Malicki, Stanislaw; Koziel, Joanna; Wong, Alicia; Bryzek, Danuta; Kantyka, Tomasz Tadeusz; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2019)
      Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD ...

    • Identification and characterization of aptameric inhibitors of human neutrophil elastase 

      Malicki, Stanisław; Książek, Mirosław; Sochaj Gregorczyk, Alicja; Kaminska, Marta; Golda, Anna; Chruścicka, Barbara; Mizgalska, Danuta; Potempa, Jan; Marti, Hans Peter; Kozieł, Joanna; Wieczorek, Maciej; Pieczykolan, Jerzy; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2023)
      Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...

    • Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe 

      Malicki, Stanisław; Pucelik, Barbara; Żyła, Edyta; Benedyk-Machaczka, Małgorzata; Gałan, Wojciech; Golda, Anna; Sochaj-Gregorczyk, Alicja; Kaminska, Marta; Encarnação, João Crispim; Chruścicka, Barbara; Marti, Hans Peter; Chen, Tony Jialiang; Magiera-Mularz, Katarzyna; Zięba, Bartosz; Holak, Tad A.; Dabrowski, Janusz M.; Czarna, Anna; Kozieł, Joanna; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2022-06-01)
      Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. ...

    • Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis 

      Hellvard, Annelie; Zeitlmann, Lutz; Heiser, Ulrich; Kehlen, Astrid; Niestroj, André; Demuth, Hans-Ulrich; Koziel, Joanna; Delaleu, Nicolas; Potempa, Jan; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2016-08-11)
      Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has ...

    • The link between periodontal disease and rheumatoid arthritis: An updated review 

      Koziel, Joanna; Mydel, Piotr Mateusz; Potempa, Jan (Peer reviewed; Journal article, 2014-01)
      Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a ...

    • Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation 

      Siddiqui, Huma; Chen, Tsute; Aliko, Ardita; Mydel, Piotr Mateusz; Jonsson, Roland; Olsen, Ingar (Peer reviewed; Journal article, 2016-10-20)
      Background: Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren’s syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have ...

    • Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts 

      Alim, M. Abdul; Njenda, Duncan; Lundmark, Anna; Kamińska, Marta; Jansson, Leif; Eriksson, Kaja; Kats, Anna; Johannsen, Gunnar; Arvidsson, Catalin Koro; Mydel, Piotr Mateusz; Yucel-Lindberg, Tülay (Journal article; Peer reviewed, 2022)
      Chronic periodontitis (CP) is a bacteria-driven inflammatory disease characterized by the breakdown of gingival tissue, the periodontal ligament, and alveolar bone, leading ultimately to tooth loss. We previously reported ...

    • Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase 

      Goulas, Theodoros; Mizgalska, Danuta; Garcia-Ferrer, Irene; Kantyka, Tomasz; Guevara, Tibisay; Szmigielski, Borys; Sroka, Aneta; Millan, Claudia; Uson, Isabel; Veillard, Florian; Potempa, Barbara; Mydel, Piotr Mateusz; Sola, Maria; Potempa, Jan; Gomis-Ruth, F. Xavier (Peer reviewed; Journal article, 2015-07-01)
      Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis, ...

    • Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal 

      Svensson, Mattias N.D.; Zoccheddu, Martina; Yang, Shen; Nygaard, Gyrid; Secchi, Christian; Doody, Karen M.; Slowikowski, Kamil; Mizoguchi, Fumitaka; Humby, Frances; Hands, Rebecca; Santelli, Eugenio; Sacchetti, Cristiano; Wakabayashi, Kuninobu; Wu, Dennis J.; Barback, Christopher; Ai, Rizi; Wang, Wei; Sims, Gary P.; Mydel, Piotr Mateusz; Kasama, Tsuyoshi; Boyle, David L.; Galimi, Francesco; Vera, David; Tremblay, Michel L.; Raychaudhuri, Soumya; Brenner, Michael B.; Firestein, Gary S.; Pitzalis, Costantino; Ekwall, Anna-Karin H.; Stanford, Stephanie M.; Bottini, Nunzio (Journal article; Peer reviewed, 2020)
      Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted ...

    • Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy 

      Nordbø, Ole Petter; Landolt, Lea Zoe; Eikrem, Øystein Solberg; Scherer, Andreas; Leh, Sabine; Furriol, Jessica; Apeland, Terje; Mydel, Piotr Mateusz; Marti, Hans Peter (Journal article; Peer reviewed, 2023)
      Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ...