• Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients 

      Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)
      Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ...
    • Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study 

      Myrstad, Marius; Kuwelker, Kanika; Haakonsen, Sigurd; Valebjørg, Therese; Langeland, Nina; Kittang, Bård Reiakvam; Hagberg, Guri; Neerland, Bjørn Erik; Bakken, Marit Stordal (Journal article; Peer reviewed, 2021)
      Purpose We aimed to study the use of The 4 ‘A’s test (4AT), a rapid delirium screening tool, performed upon Emergency Department (ED) admission, and to characterize older patients admitted to the ED with and without sepsis ...
    • Impaired glucose utilization in the brain of patients with delirium following hip fracture 

      Titlestad, Irit; Watne, Leiv; Caplan, Gideon A.; McCann, Adrian; Ueland, Per Magne; Neerland, Bjørn Erik; Myrstad, Marius; Halaas, Nathalie Bodd; Pollmann, Christian Thomas; Henjum, Kristi; Ranhoff, Anette Hylen; Solberg, Lene Bergendal; Figved, Wender; Cunningham, Colm; Melvær, Giil Lasse (Journal article; Peer reviewed, 2024)
      Alterations in brain energy metabolism have long been proposed as one of several neurobiological processes contributing to delirium. This is supported by previous findings of altered CSF lactate and neuron-specific enolase ...
    • Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study 

      Neerland, Bjørn Erik; Krogseth, Maria; Juliebø, Vibeke; Ranhoff, Anette Hylen; Engedal, Knut; Frihagen, Frede Jon; Ræder, Johan; Wyller, Torgeir Bruun; Watne, Leiv Otto (Peer reviewed; Journal article, 2017-07-10)
      Background Delirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long ...