Blar i Bergen Open Research Archive på forfatter "Nikolaienko, Oleksii"

Viser treff 1-6 av 6

    • Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer 

      Lønning, Per Eystein; Nikolaienko, Oleksii; Pan, Kathy; Kurian, Allison W.; Eikesdal, Hans Petter; Pettinger, Mary; Anderson, Garnet L.; Prentice, Ross L.; Chlebowski, Rowan T.; Knappskog, Stian (Journal article; Peer reviewed, 2022)
      Importance About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. While constitutional BRCA1 promoter methylation has been ...

    • GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation 

      Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek (Peer reviewed; Journal article, 2017-06-16)
      The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ...

    • Implication of the APP gene in intellectual abilities 

      Myrum, Craig; Nikolaienko, Oleksii; Bramham, Clive R.; Haavik, Jan; Zayats, Tetyana (Peer reviewed; Journal article, 2017)
      Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the ...

    • The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Venizelos, Andreas; Elvebakken, Hege; Perren, Aurel; Nikolaienko, Oleksii; Deng, Wei; Lothe, Inger Marie Bowitz; Couvelard, Anne; Hjortland, Geir Olav; Sundlöv, Anna; Svensson, Johanna; Garresori, Herish; Kersten, Christian; Hofsli, Eva; Detlefsen, Sönke; Krogh, Merete; Sørbye, Halfdan; Knappskog, Stian (Journal article; Peer reviewed, 2021)
      High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited, and ...

    • Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development 

      Nikolaienko, Oleksii; Eikesdal, Hans Petter; Berge, Elisabet Ognedal; Gilje, Bjørnar; Lundgren, Steinar; Blix, Egil Støre; Espelid, Helge; Geisler, Jürgen; Geisler, Stephanie; Janssen, Emiel; Yndestad, Synnøve; Minsaas, Laura; Leirvaag, Beryl; Lillestøl, Reidun Kristine; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2023)
      Background Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is ...

    • ramr: an R/Bioconductor package for detection of rare aberrantly methylated regions 

      Nikolaienko, Oleksii; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2022)
      Motivation: With recent advances in the field of epigenetics, the focus is widening from large and frequent disease- or phenotype-related methylation signatures to rare alterations transmitted mitotically or transgenerationally ...