Blar i Bergen Open Research Archive på forfatter "Nilsen, Dennis W.T."
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Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients
Aarsetøy, Reidun; ten Cate, Hugo; Spronk, Henri; Van Oerle, Rene; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Cardiac arrest and cardiopulmonary resuscitation (CPR) are associated with activated coagulation and microvascular fibrin deposition with subsequent multiorgan failure and adverse outcome. Objectives Activated ... -
Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; de la Fuente, Ricardo Leon; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a ... -
Borderline values of troponin-T and high sensitivityC-reactive protein did not predict 2-year mortality inTnTpositive chest-pain patients, whereas brain natriureticpeptide did
Nilsen, Dennis W.T.; Mjelva, Øistein; Leon de la Fuente, Ricardo; Næsgaard, Patrycja; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Stein Tore (Peer reviewed; Journal article, 2015-04-08)Background: Troponin-T (TnT), high-sensitive C-reactive protein (hsCRP), and Brain Natriuretic Peptide (BNP) have been shown to be independent prognostic indicators of total and cardiac death during short- and long-term ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ... -
Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Leon de la Fuente, Ricardo; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Nygård, Ottar Kjell; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which ... -
Effects of n-3 fatty acid supplementations in elderly patients after myocardial infarction: A randomized controlled trial
Kalstad, Are; Myhre, Peder Langeland; Laake, Kristian; Tveit, Sjur Hansen; Schmidt, Erik Berg; Smith, Pål; Nilsen, Dennis W.T.; Tveit, Arnljot; Fagerland, Morten; Solheim, Svein; Seljeflot, Ingebjørg; Arnesen, Harald (Journal article; Peer reviewed, 2021)Background: High intake of marine n-3 polyunsaturated fatty acids (PUFA) has been associated with reduced risk of cardiovascular events; however, this has not been confirmed in patients with a recent acute myocardial ... -
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas; Skogsholm, Anne; Holme, Elizabeth; van den Heuvel, Christian; Nordrehaug, Jan Erik; Bendz, Bjørn; Nilsen, Dennis W.T.; Bønaa, Kaare Harald (Journal article; Peer reviewed, 2021)Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian ... -
Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin
Dhar, Indu; Siddique, Sumia; Pedersen, Eva Kristine Ringdal; Svingen, Gard FT; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S; Nygård, Ottar (Journal article; Peer reviewed, 2020)Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ... -
N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study
Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Lindner, Thomas Werner; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2020-08-24)Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ... -
Plasma 25-hydroxyvitamin D and mortality in patients with suspected stable angina pectoris
Degerud, Eirik; Nygård, Ottar; De Vogel, Stefan; Hoff, Rune; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Dierkes, Jutta (Peer reviewed; Journal article, 2018-03)Context and Objective: Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and ... -
Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ... -
Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
Næsgaard, Patrycja A.; Pønitz, Volker; Aarsetøy, Hildegunn; Andersen, Trygve Brugger; Grundt, Heidi; Harris, William S; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2015)BACKGROUND: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. OBJECTIVES: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients ... -
The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease
Aarsetøy, Hildegunn; Grundt, Heidi; Nygård, Ottar; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2012)This paper reviews the current evidence regarding long-chained marine omega-3 polyunsaturated fatty acids (PUFAs) and cardiovascular disease (CVD), their possible mechanisms of action, and results of clinical trials. Also, ... -
Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction
Nilsen, Dennis W.T.; Myhre, Peder Langeland; Kalstad, Are; Schmidt, Erik B.; Arnesen, Harald; Seljeflot, Ingebjørg (Journal article; Peer reviewed, 2021)Dihomo-gamma-linolenic acid (DGLA) is an n-6 polyunsaturated fatty acid (PUFA) derived from linoleic acid (LA). The LA:DGLA ratio reflects conversion from LA to DGLA. Low levels of DGLA in serum have been related to poor ... -
Transsulfuration metabolites and the association with incident atrial fibrillation – An observational cohort study among Norwegian patients with stable angina pectoris
Svenningsson, Mads Malm; Svingen, Gard Frodahl Tveitevåg; Lysne, Vegard; Ueland, Per Magne; Tell, Grethe S.; Pedersen, Eva Ringdal; Dhar, Indu; Nilsen, Dennis W.T.; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background/aim Plasma total homocysteine (tHcy) is elevated in patients with persistent vs. paroxysmal atrial fibrillation (AF), and has been related to increased risk of new-onset AF. Homocysteine is degraded to cystathionine ... -
Use of loop diuretics is associated with increased mortality in patients with suspected coronary artery disease, but without systolic heart failure or renal impairment: an observational study using propensity score matching
Schartum-Hansen, Hall; Løland, Kjetil Halvorsen; Svingen, Gard Frodahl Tveitevåg; Seifert, Reinhard; Pedersen, Eva Ringdal; Nordrehaug, Jan Erik; Bleie, Øyvind; Ebbing, Marta; Berge, Christ; Nilsen, Dennis W.T.; Nygård, Ottar (Peer reviewed; Journal article, 2015-06-01)Background Loop diuretics are widely used in patients with heart and renal failure, as well as to treat hypertension and peripheral edema. However, there are no randomized, controlled trials (RCT) evaluating their long ... -
Vitamin D predicts all-cause and cardiac mortality in females with suspected acute coronary syndrome: a comparison with brain natriuretic peptide and high-sensitivity C-reactive protein
Næsgaard, Patrycja; Fuente, Ricardo León de la; Nilsen, Stein Tore; Woie, Leik; Årsland, Torbjørn; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2013)Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac ... -
Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction
Næsgaard, Patrycja; Grundt, Heidi; Nordøy, Arne; Staines, Harry; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2017-07-24)Background: Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. Objectives: We investigated the impact of a purified high-dose omega-3 compound ...