Blar i Bergen Open Research Archive på forfatter "Nilsen, Roy Miodini"
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450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy
Joubert, Bonnie R.; Håberg, Siri Eldevik; Nilsen, Roy Miodini; Wang, Xuting; Vollset, Stein Emil; Murphy, Susan K; Huang, Zhiqing; Hoyo, Cathrine; Midttun, Øivind; Cupul-Uicab, Lea A; Ueland, Per Magne; Wu, Michael C; Nystad, Wenche; Bell, Douglas A; Peddada, Shyamal D; London, Stephanie J (Peer reviewed; Journal article, 2012-10)Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple ... -
The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital inpatients: results from a Norwegian multicentre, observational cohort study
Wathne, Jannicke Slettli; Harthug, Stig; Kleppe, Lars Kåre Selland; Blix, Hege Salvesen; Nilsen, Roy Miodini; Charani, Esmita; Smith, Ingrid (Peer reviewed; Journal article, 2019-04-15)Background: Clinical antibiotic prescribing guidelines are essential in defining responsible use in the local context. Our objective was to investigate the association between adherence to national antibiotic prescribing ... -
Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
Johannessen, Ane; Lønnebotn, Marianne; Calciano, Lucia; Benediktsdóttir, Bryndís; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali; Franklin, Karl A.; Gíslason, Þórarinn; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Jõgi, Rain; Kim, Jeong-Lim; Kirkeleit, Jorunn; Lodge, Caroline; Malinovschi, Andrei; Martinez-Moratalla, Jesus; Nilsen, Roy Miodini; Pereira-Vega, Antonio; Gomez Real, Francisco; Schlünssen, Vivi; Accordini, Simone; Svanes, Cecilie (Peer reviewed; Journal article, 2020-03)Background Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. ... -
Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison’s Disease: A Randomized Clinical Trial
Øksnes, Marianne; Björnsdottir, Sigridur; Isaksson, Magnus; Methlie, Paal; Carlsen, Siri; Nilsen, Roy Miodini; Broman, Jan-Erik; Triebner, Kai; Kämpe, Olle; Hulting, Anna-Lena; Bensing, Sophie; Husebye, Eystein Sverre; Løvås, Kristian (Peer reviewed; Journal article, 2014)Context: Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison’s disease. Objective: The objective ... -
Country of first birth and neonatal outcomes in migrant and Norwegian-born parous women in Norway: a population-based study
Vik, Eline Skirnisdottir; Nilsen, Roy Miodini; Aasheim, Vigdis; Small, Rhonda; Moster, Dag; Schytt, Erica (Journal article; Peer reviewed, 2020)Background This study compares subsequent birth outcomes in migrant women who had already had a child before arriving in Norway with those in migrant women whose first birth occurred in Norway. The aim of this study was ... -
Diet matters, particularly in pregnancy - results from MoBa studies of maternal diet and pregnancy outcomes
Brantsæter, Anne Lise; Haugen, Margaretha; Myhre, Ronny; Sengpiel, Verena; Englund-Ögge, Linda; Nilsen, Roy Miodini; Borgen, Iren; Duarte-Salles, Talita; Papadopoulou, Eleni; Vejrup, Kristine; von Ruesten, Anne; Hillesund, Elisabet Rudjord; Birgisdottir, Bryndis Eva; Magnus, Per; Trogstad, Lill; Jacobsson, Bo; Bacelis, Jonas; Myking, Solveig; Knutsen, Helle Katrine; Kvalem, Helen Engelstad; Alexander, Jan; Mendez, Michelle; Meltzer, Helle Margrete (Peer reviewed; Journal article, 2014)Awareness that maternal diet may influence the outcome of pregnancy as well as the long-term health of mother and child has increased in recent years. A new food frequency questionnaire (FFQ) was developed and validated ... -
Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
Boge, Ranveig Marie; Haugen, Arvid Steinar; Nilsen, Roy Miodini; Bruvik, Frøydis Kristine; Harthug, Stig (Peer reviewed; Journal article, 2019)Background: The Discharge Care Experiences Survey (DICARES) was previously developed to measure quality of discharge care in elderly patients (≥ 65 years). The objective of this study was to test the factorial validity of ... -
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy
Reese, Sarah E; Zhao, Shanshan; Wu, Michael C; Joubert, Bonnie R; Parr, Christine Louise; Håberg, Siri Eldevik; Ueland, Per Magne; Nilsen, Roy Miodini; Midttun, Øivind; Vollset, Stein Emil; Peddada, Shyamal D; Nystad, Wenche; London, Stephanie J (Peer reviewed; Journal article, 2017-04)Background: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up ... -
Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study
Husabø, Gunnar; Nilsen, Roy Miodini; Flaatten, Hans; Solligård, Erik; Frich, Jan C; Bondevik, Gunnar Tschudi; Braut, Geir Sverre; Walshe, Kieran; Harthug, Stig; Hovlid, Einar (Peer reviewed; Journal article, 2020-01-22)Background: Early recognition of sepsis is critical for timely initiation of treatment. The first objective of this study was to assess the timeliness of diagnostic procedures for recognizing sepsis in emergency departments. ... -
The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: A multicentre, cluster randomized controlled intervention study
Wathne, Jannicke Slettli; Kleppe, Lars Kåre Selland; Harthug, Stig; Blix, Hege Salvesen; Nilsen, Roy Miodini; Charani, Esmita; Smith, Ingrid (Peer reviewed; Journal article, 2018-09-10)Background: There is limited evidence from multicenter, randomized controlled studies to inform planning and implementation of antibiotic stewardship interventions in hospitals. Methods: A cluster randomized, controlled, ... -
The effect of low dose marine protein hydrolysates on short-term recovery after high intensity performance cycling: A double-blinded crossover study
Mjøs, Ingunn; Thorsen, Einar; Hausken, Trygve; Lied, Einar; Nilsen, Roy Miodini; Brønstad, Ingeborg; Edvardsen, Elisabeth; Frisk, Bente (Peer reviewed; Journal article, 2019)Background: Knowledge of the effect of marine protein hydrolysate (MPH) supplementation to promote recovery after high intensity performance training is scarce. The aim of this study was to examine the effect of MPH ... -
Effects of external inspection on sepsis detection and treatment: a study protocol for a quasiexperimental study with a stepped-wedge design
Hovlid, Einar; Frich, Jan C; Walshe, Kieran; Nilsen, Roy Miodini; Flaatten, Hans; Braut, Geir Sverre; Helgeland, Jon; Teig, Inger Lise; Harthug, Stig (Peer reviewed; Journal article, 2017)Introduction: Inspections are widely used in health care as a means to improve the health services delivered to patients. Despite their widespread use, there is little evidence of their effect. The mechanisms for how ... -
Effects of external inspections on sepsis detection and treatment: a stepped-wedge study With cluster-level randomisation
Husabø, Gunnar; Nilsen, Roy Miodini; Solligård, Erik; Flaatten, Hans; Walshe, Kieran; Frich, Jan C; Bondevik, Gunnar Tschudi; Braut, Geir Sverre; Helgeland, Jon; Harthug, Stig; Hovlid, Einar (Journal article; Peer reviewed, 2020)Objective To evaluate the effects of external inspections on (1) hospital emergency departments’ clinical processes for detecting and treating sepsis and (2) length of hospital stay and 30-day mortality. Design Incomplete ... -
Elderly patients’ (≥65 years) experiences associated with discharge; Development, validity and reliability of the Discharge Care Experiences Survey
Boge, Ranveig Marie; Haugen, Arvid Steinar; Nilsen, Roy Miodini; Harthug, Stig (Peer reviewed; Journal article, 2018-11-07)Background: A review of the literature reveals a lack of validated instruments that particularly measure quality in the hospital discharge process. This study aims to develop and validate a survey instrument feasible for ... -
Electronic capturing of patient-reported outcome measures on a touchscreen computer in clinical diabetes practice (the DiaPROM trial): a feasibility study
Hernar, Ingvild; Graue, Marit; Richards, David A; Strandberg, Ragnhild Bjarkøy; Nilsen, Roy Miodini; Tell, Grethe S.; Haugstvedt, Anne (Peer reviewed; Journal article, 2019-02-20)Background: Living with type 1 diabetes (T1D) is demanding, and emotional problems may impair ability for diabetes self-management. Thus, diabetes guidelines recommend regular assessment of such problems. Using patient-reported ... -
Epidural analgesia for labour pain in nulliparous women in Norway in relation to maternal country of birth and migration related factors
Aasheim, Vigdis; Nilsen, Roy Miodini; Vik, Eline Skirnisdottir; Small, Rhonda; Schytt, Erica (Journal article; Peer reviewed, 2020)Objective To investigate associations between maternal country of birth and other migration related factors (length of residence, reason for migration, paternal origin) and epidural analgesia for labour pain in nulliparous ... -
Factors associated with change in health-related quality of life among individuals treated with long-term mechanical ventilation, a 6-year follow-up study
Markussen, Heidi Øksnes; Lehmann, Sverre; Nilsen, Roy Miodini; Natvig, Gerd Karin (Peer reviewed; Journal article, 2018-03)Aims: To examine changes and explanatory variables for changes in health-related quality of life in patients treated with long-term mechanical ventilation over a 6-year period. Background: Long-term mechanical ventilation ... -
Factors influencing the development of evidence-based practice among nurses: a self-report survey
Dalheim, Anne; Harthug, Stig; Nilsen, Roy Miodini; Nortvedt, Monica Wammen (Peer reviewed; Journal article, 2012-10-24)Background: Health authorities in several countries have decided that the health care services should be evidence-based. Recent research indicates that evidence-based practice may be more successfully implemented if the ... -
Females report higher postoperative pain scores than males after ankle surgery
Storesund, Anette; Krukhaug, Yngvar; Olsen, Marit Vassbotten; Rygh, Lars Jørgen; Nilsen, Roy Miodini; Norekvål, Tone M. (Peer reviewed; Journal article, 2016-07)Objectives: The majority of patients experience moderate-to-intense pain following ankle surgery. Early, adequate treatment of postoperative pain is desirable for optimal pain relief, which in turn may facilitate optimal ... -
Folate and reproductive health. An epidemiologic study of folic acid supplement use and its relation to birth outcomes in Norwegian pregnant women
Nilsen, Roy Miodini (Doctoral thesis, 2010-04-23)Background: Randomized trials and observational studies have consistently shown that maternal intake of folic acid supplements before and early in pregnancy reduces the risk of neural tube defects in infants. These reports ...