Blar i Bergen Open Research Archive på forfatter "Nordgård, Oddmund"
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Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
Søreide, Kjetil; Watson, Martin M; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne R (Peer reviewed; Journal article, 2016-06-29)Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ... -
Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I–III colon cancers
Berg, Marianne; Guriby, Marianne; Nordgård, Oddmund; Nedrebø, Bjørn Steinar Olden; Ahlquist, Terje Cruickshank; Smaaland, Rune; Oltedal, Satu; Søreide, Jon Arne; Kørner, Hartwig; Lothe, Ragnhild A.; Søreide, Kjetil (Peer reviewed; Journal article, 2013)Lymph node (LN) harvest is influenced by several factors, including tumor genetics. Microsatellite instability (MSI) is associated with improved node harvest, but the association to other genetic factors is largely unknown. ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
Berg, Marianne; Nordgård, Oddmund; Kørner, Hartwig; Oltedal, Satu; Smaaland, Rune; Søreide, Jon Arne; Søreide, Kjetil (Peer reviewed; Journal article, 2015-04-16)Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods: We sought to investigate various molecular subtypes ... -
Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma
Choi, Man Hung; Mejlænder-Andersen, Eline; Manueldas, Sophia; el Jellas, Khadija; Steine, Solrun; Tjensvoll, Kjersti; Sætran, Hege Aase; Knappskog, Stian; Hoem, Dag; Nordgård, Oddmund; Hovland, Randi; Molven, Anders (Peer reviewed; Journal article, 2019-01-05)Background Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ... -
Platelet microparticles decrease daunorubicin‐induced dna damage and modulate intrinsic apoptosis in thp‐1 cells
Cacic, Daniel; Nordgård, Oddmund; Meyer, Peter Albert; Hervig, Tor (Journal article; Peer reviewed, 2021)Platelets can modulate cancer through budding of platelet microparticles (PMPs) that can transfer a plethora of bioactive molecules to cancer cells upon internalization. In acute myelogenous leukemia (AML) this can induce ... -
Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis
Cacic, Daniel; Reikvam, Håkon; Nordgård, Oddmund; Meyer, Peter; Hervig, Tor (Journal article; Peer reviewed, 2021)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ... -
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
Lind, Guro Elisabeth; Guriby, Marianne; Ahlquist, Terje Cruickshank; Hussain, Israr; Jeanmougin, Marine; Søreide, Kjetil; Kørner, Hartwig; Lothe, Ragnhild A; Nordgård, Oddmund (Peer reviewed; Journal article, 2017-09-05)Background: Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marker ...