Browsing Bergen Open Research Archive by Author "Norrby-Teglund, Anna"

Now showing items 1-8 of 8

    • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections 

      Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)
      Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ...

    • Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections 

      Gundersen, Ingunn Margareetta; Berget, Ellen; Haugland, Hans Kristian; Bruun, Trond; Almeland, Stian Kreken; Assmus, Jörg; Rath, Eivind; Norrby-Teglund, Anna; Skrede, Steinar; Mosevoll, Knut Anders (Journal article; Peer reviewed, 2022)
      Background Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend tissue biopsies as an adjunct diagnostic in routine ...

    • Consistent biofilm formation by Streptococcus pyogenes emm 1 isolated from patients with necrotizing soft tissue infections 

      Skutlaberg, Dag Harald; Wiker, Harald Gotten; Mylvaganam, Haima; Norrby-Teglund, Anna; Skrede, Steinar (Journal article; Peer reviewed, 2022-02-18)
      Objectives: Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this ...

    • Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections 

      Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Vries, Annebeth Meij-de; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P. (Journal article; Peer reviewed, 2022)
      Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ...

    • Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections 

      Siemens, Nikolai; Kittang, Bård Reiakvam; Chakrakodi, Bhavya; Oppegaard, Oddvar; Johansson, Linda; Bruun, Trond; Mylvaganam, Haima; Svensson, Mattias; Skrede, Steinar; Norrby-Teglund, Anna (Peer reviewed; Journal article, 2015)
      Streptococcus dysgalactiae subsp. equisimilis (SDSE) has emerged as an important cause of severe skin and soft tissue infections, but little is known of the pathogenic mechanisms underlying tissue pathology. Patient samples ...

    • Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability 

      Movert, Elin; Bolarin, Jaume Salgado; Valfridsson, Christine; Velarde, Jorge; Skrede, Steinar; Nekludov, Michael; Hyldegaard, Ole; Arnell, Per; Svensson, Mattias; Norrby-Teglund, Anna; Cho, Kyu Hong; Elhaik, Eran; Wessels, Michael R.; Råberg, Lars; Carlsson, Fredric (Journal article; Peer reviewed, 2023)
      Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ...

    • Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes 

      Shumba, Patience; Sura, Thomas; Moll, Kirsten; Chakrakodi, Bhavya; Tölken, Lea A.; Hoßmann, Jörn; Hoff, Katharina J.; Hyldegaard, Ole; Nekludov, Michael; Svensson, Mattias; Arnell, Per; Skrede, Steinar; Norrby-Teglund, Anna; Siemens, Nikolai (Journal article; Peer reviewed, 2023)
      Background Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information ...

    • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study 

      Rath, Eivind; Palma Medina, Laura M.; Jahagirdar, Sanjeevan; Mosevoll, Knut Anders; Damås, Jan Kristian; Madsen, Martin B.; Svensson, Mattias; Hyldegaard, Ole; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Norrby-Teglund, Anna; Skrede, Steinar; Bruun, Trond (Journal article; Peer reviewed, 2023)
      Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ...