Browsing Bergen Open Research Archive by Author "Nygård, Gyrid"
Now showing items 1-2 of 2
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Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells
Myhren, Lene Elisabeth; Nygård, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Døskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Peer reviewed; Journal article, 2013-01-30)Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ... -
Marine Benthic Diatoms Contain Compounds Able to Induce Leukemia Cell Death and Modulate Blood Platelet Activity
Prestegard, Siv Kristin; Oftedal, Linn Silje Wathne; Coyne, Rosie Theresa; Nygård, Gyrid; Skjærven, Kaja Helvik; Knutsen, Gjert; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2009-11-18)In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in ...