Browsing Bergen Open Research Archive by Author "Nygård, Ottar Kjell"
Now showing items 1-19 of 19
-
Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study
Van Parys, Anthea; Lysne, Vegard; Dierkes, Jutta; Nygård, Ottar Kjell; Øyen, Jannike; Vinknes, Kathrine Jørgensen; Karlsson, Therese; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Ueland, Per Magne; Brække, Maria Sandvik (Journal article; Peer reviewed, 2022)Background: Choline is an essential nutrient for humans and is involved in various physiologic functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism, and the fat-soluble choline ... -
The association between dairy intake and risk of cardiovascular disease and mortality in patients with stable angina pectoris
Parys, Anthea van; Sæle, Jostein; Puaschitz, Nathalie; Anfinsen, Åslaug Matre; Karlsson, Therese; Olsen, Thomas; Haugsgjerd, Teresa Risan; Vinknes, Kathrine Jørgensen; Holven, Kirsten Bjørklund; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2022)Aims The association of dairy products with cardiovascular disease and mortality risk remains heavily debated. We aimed to investigate the association between intake of total dairy and dairy products and the risk of acute ... -
B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Bjørnestad, Espen Øglænd; Ulvik, Arve; Saeed, Sahrai; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ... -
Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study
Grytten, Elise; Laupsa-Borge, Johnny; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; Skorve, Jon; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Background & aims Marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower circulating levels of triacylglycerols (TAGs), and the plant-derived ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Ørn, Stein; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Comparison of nutritional risk screening with NRS2002 and the GLIM diagnostic criteria for malnutrition in hospitalized patients
Trollebø, Marte Almenning; Skeie, Eli; Revheim, Ingrid; Stangeland, Helene; Erstein, Mari-Anne Heggelien; Grønning, Martin Kristoffer; Tangvik, Randi Julie; Morken, Mette Helvik; Nygård, Ottar Kjell; Eagan, Tomas Mikal Lind; Rosendahl-Riise, Hanne; Dierkes, Jutta (Journal article; Peer reviewed, 2022)Nutritional risk screening, to identify patients at risk of malnutrition, is the first step in the prevention and treatment of malnutrition in hospitalized patients, and should be followed by a thorough nutritional assessment ... -
Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Leon de la Fuente, Ricardo; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Nygård, Ottar Kjell; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)Background Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which ... -
Even chained acylcarnitines predict long-term cardiovascular prognosis in patients with chest pain and non-obstructive coronary artery disease
Storesund, Silje Kjellevold; Karaji, Iman; Strand, Elin; Svardal, Asbjørn M.; Lønnebakken, Mai Tone; Berge, Rolf Kristian; Svingen, Gard Frodahl Tveitevåg; Nygård, Ottar Kjell; Pedersen, Eva Ringdal (Journal article; Peer reviewed, 2022)Background Acylcarnitines are essential for mitochondrial fatty acid oxidation. Earlier studies suggest that impaired energy metabolism may be implicated in the pathogenesis of microvascular angina. We explored metabolites ... -
Exploratory analyses on the effect of time since last meal on concentrations of amino acids, lipids, one-carbon metabolites, and vitamins in the Hordaland Health Study
Anfinsen, Åslaug Matre; Rosendahl-Riise, Hanne; Nygård, Ottar Kjell; Tell, Grethe S.; Ueland, Per Magne; Ulvik, Arve; McCann, Adrian; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)Purpose Dietary intake may have pronounced effects on circulating biomarker concentrations. Therefore, the aim was to provide a descriptive overview of serum metabolite concentrations in relation to time since last meal, ... -
Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients With Stable Angina Pectoris
Van Parys, Anthea; Karlsson, Therese; Vinknes, Kathrine; Olsen, Thomas; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2021)Background: Choline is an essential nutrient involved in a wide range of physiological functions. It occurs in water- and lipid-soluble forms in the body and diet. Foods with a known high choline content are eggs, beef, ... -
Hepatic Energy Metabolism Underlying Differential Lipidomic Responses to High-Carbohydrate and High-Fat Diets in Male Wistar Rats
Dankel, Simon N; Bjørndal, Bodil; Lindquist, Carine; Grinna, Mari Lausund; Rossmann, Christine Renate; Bohov, Pavol; Nygård, Ottar Kjell; Hallstrom, Seth; Strand, Elin; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Background Low-carbohydrate diets are suggested to exert metabolic benefits by reducing circulating triacylglycerol (TG) concentrations, possibly by enhancing mitochondrial activity. Objective We aimed to elucidate ... -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2022)The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ... -
No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris
Van Parys, Anthea; Lysne, Vegard; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell (Journal article, 2020)Plasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Ulvik, Arve; Bjørnestad, Espen Øglænd; Dankel, Simon N; Mellgren, Gunnar; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Primary cardiovascular risk prediction by LDL-cholesterol in Caucasian middle-aged and older adults: a joint analysis of three cohorts
Hilvo, Mika; Dhar, Indu; Lääperi, Mitja; Lysne, Vegard; Sulo, Gerhard; Tell, Grethe S.; Jousilahti, Pekka; Nygård, Ottar Kjell; Brenner, Hermann; Schöttker, Ben; Laaksonen, Reijo (Journal article; Peer reviewed, 2022)Aims Low-density lipoprotein cholesterol (LDL-C) is an established causal driver of atherosclerotic cardiovascular disease (ASCVD), but its performance and age-dependency as a biomarker for incident events and mortality ... -
Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study
Laupsa-Borge, Johnny; Grytten, Elise; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; SKORVE, JON; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background: Clinical studies on effects of marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the plant-derived omega-6 (n-6) PUFA ... -
Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Ørn, Stein; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Aims Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). ... -
Within-person reproducibility of proteoforms related to inflammation and renal dysfunction
Gao, Jie; McCann, Adrian; Laupsa-Borge, Johnny; Nygård, Ottar Kjell; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2022)Protein biomarkers and microheterogeneity have attracted increasing attention in epidemiological and clinical research. Knowledge of within-person reproducibility over time is paramount to determine whether a single ... -
β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Lysne, Vegard; Bjørnestad, Espen Øglænd; Ueland, Per Magne; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)Aims Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in ...