• Bowel Perfusion Measured with Dynamic Contrast-enhanced Ultrasound Predicts Treatment Outcome in Patients with Crohn’s Disease 

      Sævik, Fredrik Eriksen; Nylund, Kim; Hausken, Trygve; Ødegaard, Svein; Gilja, Odd Helge (Peer reviewed; Journal article, 2014-09-02)
      Background: To improve management of patients with Crohn's disease (CD), objective measurements of the degree of local inflammation in the gastrointestinal wall are needed. Increased microvessel density and perfusion are ...
    • Development and Validation of a Simple Ultrasound Activity Score for Crohn’s Disease 

      Sævik, Fredrik Bjorvatn; Eriksen, Ragnar; Eide, Geir Egil; Gilja, Odd Helge; Nylund, Kim (Journal article; Peer reviewed, 2020-06-06)
      Background and Aims To improve management of patients with Crohn’s disease, objective measurements of disease activity are needed. Ileocolonoscopy is the current reference standard but has limitations that restrict repeated ...
    • Gastrointestinal Ultrasound Can Predict Endoscopic Activity in Crohn’s Disease 

      Sævik, Fredrik; Gilja, Odd Helge; Nylund, Kim (Journal article; Peer reviewed, 2020-04-24)
      Purpose To explore the ability of gastrointestinal ultrasound (GIUS) to separate patients in endoscopic remission from patients with active disease in a heterogeneous hospital cohort with Crohn’s disease (CD). Materials ...
    • Plasma levels of guanylins are reduced in patients with Crohn’s disease 

      Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Tronstad, Rune Rose; Dizdar, Vernesa; Nylund, Kim; Hanevik, Kurt; Hausken, Trygve; Gilja, Odd Helge; Fiskerstrand, Torunn (Journal article; Peer reviewed, 2020)
      Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid homeostasis. Gene expression and protein levels of ...
    • Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation 

      Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Gilja, Odd Helge; Tronstad, Rune Rose; Sangnes, Dag André; Nortvedt, Ragnar; Hausken, Trygve; Dimcevski, Georg Gjorgji; Fiskerstrand, Torunn; Nylund, Kim (Peer reviewed; Journal article, 2017)
      Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ...
    • Ultrasound imaging for assessing functions of the GI tract 

      Steinsvik, Elisabeth Kjelsvik; Hatlebakk, Jan Gunnar; Hausken, Trygve; Nylund, Kim; Gilja, Odd Helge (Journal article; Peer reviewed, 2021)
      Objective: In the following review we outline how ultrasound can be used to measure physiological processes in the gastrointestinal tract. Approach: We have investigated the potential of ultrasound in assessing ...
    • Ultrasound in Crohn’s Disease - bowel wall characteristics and perfusion estimates using microbubbles 

      Nylund, Kim (Doctoral thesis; Peer reviewed, 2013-01-18)
      Crohn’s disease (CD) is a chronic inflammatory bowel disease which often presents early in life and sometimes can be debilitating. The patients need frequent diagnostic work-up to assess disease activity, location, extent ...