Browsing Bergen Open Research Archive by Author "Ohba, Shigeo"

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    • Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity 

      Ohba, Shigeo; Johannessen, Tor-Christian Aase; Chatla, Kamalakar; Yang, Xiaodong; Pieper, Russell O.; Mukherjee, Joydeep (Journal article; Peer reviewed, 2020)
      The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is ...

    • PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas 

      Ohba, Shigeo; Tang, Yongjian; Johannessen, Tor-Christian Aase; Mukherjee, Joydeep (Journal article; Peer reviewed, 2022)
      PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ...