• Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease 

      Kvivik, Ingeborg; Grimstad, Tore Bjørn; Jonsson, Grete; Kvaløy, Jan T.; Omdal, Roald (Journal article; Peer reviewed, 2021)
      Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ...
    • Determination of lower cut-off levels of adalimumab associated with biochemical remission in Crohn's disease 

      Carlsen, Arne; Omdal, Roald; Karlsen, Lars Normann; Kvaløy, Jan Terje; Aabakken, Lars; Steinsbø, Øyvind; Bolstad, Nils; Warren, David; Lundin, Knut Erik Aslaksen; Grimstad, Tore (Peer reviewed; Journal article, 2020)
      Background and Aim: Adalimumab is administered and dosed using a standardized treatment regimen. Although therapeutic drug monitoring (TDM) may help optimize treatment efficacy, the lower cut‐off concentration of adalimumab ...
    • Fatigue in celiac disease: A review of the literature 

      Skjellerudsveen, Berit M.; Omdal, Roald; Grimstad, Tore (Peer reviewed; Journal article, 2019)
      Fatigue is increasingly recognized as a significant problem in patients with chronic inflammatory and autoimmune diseases. In celiac disease, a chronic immune‐mediated disease triggered by dietary gluten, conflicting ...
    • Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid 

      Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Journal article; Peer reviewed, 2019)
      Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ...
    • Fatigue in psoriasis: a phenomenon to be explored 

      Skoie, Inger Marie; Ternowitz, Thomas; Jonsson, Grete; Norheim, Katrine Brække; Omdal, Roald (Peer reviewed; Journal article, 2015-05)
      Fatigue is a prevalent and substantial phenomenon in many patients with chronic inflammatory diseases, often rated by patients as the most troublesome symptom and aspect of their disease. It frequently interferes with ...
    • Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome 

      Thorlacius, Gudny Ella; Hultin-Rosenberg, Lina; Sandling, Johanna K.; Bianchi, Matteo; Imgenberg-Kreuz, Juliana; Theander, Elke; Kvarnström, Marika; Forsblad-d’Elia, Helena; Bucher, Sara Magnusson; Norheim, Katrine Brække; Johnsen, Svein Joar Auglænd; Hammenfors, Sten Daniel; Skarstein, Kathrine; Jonsson, Malin V; Bäcklund, Eva; consortium, the DISSECT; meadows, jennifer r; Rantapää-Dahlqvist, Solbritt; Mandl, Thomas; Eriksson, Per; Omdal, Roald; Jonsson, Sten Ture Roland; Lindblad-Toh, Kerstin; Rönnblom, Lars; Wahren-Herlenius, Marie; Nordmark, Gunnel (Journal article; Peer reviewed, 2020)
      Objectives Clinical presentation of primary Sjögren’s syndrome (pSS) varies considerably. A shortage of evidence-based objective markers hinders efficient drug development and most clinical trials have failed to reach ...
    • Heat shock proteins and chronic fatigue in primary Sjögren's syndrome 

      Bårdsen, Kjetil; Mæland, Mari; Kvaløy, Jan Terje; Norheim, Katrine Brække; Jonsson, Grete; Omdal, Roald (Peer reviewed; Journal article, 2016)
      Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system ...
    • Heat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s disease 

      Grimstad, Tore; Kvivik, Ingeborg; Kvaløy, Jan Terje; Aabakken, Lars; Omdal, Roald (Peer reviewed; Journal article, 2020)
      Heat-shock proteins (HSPs) are evolutionarily conserved proteins with important cellular homeostasis functions during harmful conditions, including inflammation. Some HSPs are secreted extracellularly and act on distant ...
    • Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial 

      Norheim, Katrine Brække; Harboe, Erna; Gøransson, Lasse Gunnar; Omdal, Roald (Peer reviewed; Journal article, 2012)
      Objectives Fatigue is a major cause of disability in primary Sjögren's syndrome (pSS). Fatigue has similarities with sickness behaviour in animals; the latter mediated by pro-inflammatory cytokines, in particular interleukin ...
    • Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome 

      Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Journal article; Peer reviewed, 2019)
      Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...
    • Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing 

      Sandling, Johanna K.; Pucholt, Pascal; Hultin Rosenberg, Lina; Farias, Fabiana H.G.; Kozyrev, Sergey V.; Eloranta, Maija-Leena; Alexsson, Andrei; Bianchi, Matteo; Padyukov, Leonid; Bengtsson, Christine; Jonsson, Roland; Omdal, Roald; Lie, Benedicte Alexandra; Massarenti, Laura; Steffensen, Rudi; Jakobsen, Marianne A.; Lillevang, Søren T.; Lerang, Karoline; Molberg, Øyvind; Voss, Anne; Troldborg, Anne; Jacobsen, Søren; Syvänen, Ann-Christine; Jönsen, Andreas; Gunnarsson, Iva; Svenungsson, Elisabet; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Sjöwall, Christopher; Leonard, Dag; Lindblad-Toh, Kerstin; Rönnblom, Lars (Journal article, 2021)
      Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ...
    • Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome 

      Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Zetterberg, Henrik; Kvaløy, Jan Terje; Kvivik, Ingeborg; Maroni, Stian; Greve, Ole Jacob; Beyer, Mona K.; Hirohata, Shunsei; Putterman, Chaim; Alves, Guido Werner; Harboe, Erna; Blennow, Kaj; Gøransson, Lasse; Omdal, Roald (Journal article; Peer reviewed, 2020)
      Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ...
    • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

      Grimstad, Tore; Bjørndal, Bodil; Cacabelos, Daniel; Aasprong, Ole Gunnar; Omdal, Roald; Svardal, Asbjørn M.; Bohov, Pavol; Pamplona, Reinald; Portero-Otin, Manuel; Berge, Rolf Kristian; Hausken, Trygve (Peer reviewed; Journal article, 2013-01-10)
      Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...
    • Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein 

      Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Journal article; Peer reviewed, 2021)
      Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ...
    • Severe headache in primary Sjögren's syndrome treated with intrathecal rituximab 

      Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Norheim, Katrine Brække; Omdal, Roald (Peer reviewed; Journal article, 2019-01-17)
      A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B‐cell ...