Blar i Bergen Open Research Archive på forfatter "Oveland, Eystein"
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Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Døskeland, Stein Ove; Selheim, Frode (Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ... -
Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
Bjørkum, Alvhild Alette; Oveland, Eystein; Stuhr, Linda Elin Birkhaug; Havnes, Marianne Bjordal; Berven, Frode; Grønning, Marit; Hope, Arvid (Peer reviewed; Journal article, 2017-10-04)Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present ... -
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
Guldbrandsen, Astrid; Vethe, Heidrun; Farag, Yehia Mohamed Mokhtar; Oveland, Eystein; Garberg, Hilde Kristin; Berle, Magnus Foldal; Myhr, Kjell-Morten; Opsahl, Jill Anette; Barsnes, Harald; Berven, Frode (Peer reviewed; Journal article, 2014-11)In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode reversed phase-anion exchange for mapping the global CSF ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
Haslene-Hox, Hanne; Oveland, Eystein; Berg, Kaja Christine Graue; Kolmannskog, Odd; Woie, Kathrine; Salvesen, Helga Birgitte; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid
Berle, Magnus; Kroksveen, Ann Cathrine; Haaland, Øystein; Aye, Thin T.; Opsahl, Jill Anette; Oveland, Eystein; Wester, Knut; Ulvik, Rune Johan; Helland, Christian Andre; Berven, Frode S. (Peer reviewed; Journal article, 2011-05-20)Background: The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goals ... -
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
Yadetie, Fekadu; Bjørneklett, Silje; Garberg, Hilde K; Oveland, Eystein; Berven, Frode; Goksøyr, Anders; Karlsen, Odd André (Peer reviewed; Journal article, 2016-08-05)Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ... -
Viewing the proteome: How to visualize proteomics data?
Oveland, Eystein; Muth, Thilo; Rapp, Erdmann; Martens, Lennart; Berven, Frode; Barsnes, Harald (Peer reviewed; Journal article, 2015-04)Proteomics has become one of the main approaches for analyzing and understanding biological systems. Yet similar to other high-throughput analysis methods, the presentation of the large amounts of obtained data in easily ...