Browsing Bergen Open Research Archive by Author "Paulo, Joao A."
Now showing items 1-9 of 9
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The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop
Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik; Unger, Lucas; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne; Ghila, Luiza Mihaela; Chera, Simona (Journal article; Peer reviewed, 2024)Animal longevity is a function of global vital organ functionality and, consequently, a complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific ageing exist, owing their conservation to ... -
Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors
Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne Bjørnson; Ræder, Helge; Chera, Simona (Journal article; Peer reviewed, 2021-04-02)The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms ... -
The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation
Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019-05-08)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab; Strand, Berit Løkensgard; Scholz, Hanne; Paulo, Joao A.; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating ... -
Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model
Bjørnstad, Ole Vidhammer; Carrasco Fernandez, Manuel; Finne, Kenneth; Ardawatia, Vandana; Winge, Ingeborg; Askeland, Cecilie; Arnes, Jarle; Knutsvik, Gøril; Kleftogiannis, Dimitrios; Paulo, Joao A.; Akslen, Lars Andreas; Vethe, Heidrun (Journal article; Peer reviewed, 2024)Background Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is emerging. A recent ... -
Hypoxia induced responses are reflected in the stromal proteome of breast cancer
Kjølle, Silje; Finne, Kenneth; Birkeland, Even; Ardawatia, Vandana; Winge, Ingeborg; Aziz, Sura Mohammed; Knutsvik, Gøril; Wik, Elisabeth; Paulo, Joao A.; Vethe, Heidrun; Kleftogiannis, Dimitrios; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) ... -
In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun; Abadpour, Shadab; Mathisen, Andreas; Paulo, Joao A.; Scholz, Hanne; Ræder, Helge; Chera, Simona (Peer reviewed; Journal article, 2020)Aim: The loss of insulin‐secreting β‐cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into ... -
Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature
Berle, Magnus; Hestetun, Kjersti Elvestad; Vethe, Heidrun; Chera, Simona; Paulo, Joao A.; Dahl, Olav; Myklebust, Mette Pernille (Journal article; Peer reviewed, 2022)Background/Aim: Better stratification of the risk of relapse will help select the right patients for adjuvant treatment and improve targeted therapies for patients with colon cancer. Materials and Methods: To understand ... -
Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells
Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...