Browsing Bergen Open Research Archive by Author "Pedersen, Kenn Freddy"
Now showing items 1-8 of 8
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Apathy in Parkinson’s disease. A community-based study
Pedersen, Kenn Freddy (Doctoral thesis, 2010-04-09) -
Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease
Oftedal, Linn Silje Wathne; Maple-Grødem, Jodi; Dalen, Ingvild; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2022)Background and Objectives Variations in the glucocerebrosidase gene (GBA) are common risk factors for Parkinson disease (PD) and dementia in PD (PDD) and cause a reduction in the activity of the lysosomal enzyme ... -
Cognitive Profile in Parkinson’s Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta
Tufekcioglu, Zeynep; Lange, Johannes; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Emre, Murat (Journal article; Peer reviewed, 2023)Introduction: In patients with Parkinson’s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, ... -
Evolution of impulsive–compulsive behaviors and cognition in Parkinson’s disease
Erga, Aleksander Hagen; Alves, Guido Werner; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy (Peer reviewed; Journal article, 2020)The longitudinal course of ICBs in patients with Parkinson’s disease (PwP) relative to controls has not been explored as of yet. The aim of this study is to determine the frequency, evolution and associated cognitive and ... -
GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study
Szwedo, Aleksandra Anna; Dalen, Ingvild; Pedersen, Kenn Freddy; Camacho, Marta; Bäckström, David; Forsgren, Lars; Tzoulis, Charalampos; Winder-Rhodes, Sophie; Hudson, Gavin; Liu, Ganqiang; Scherzer, Clemens R.; Lawson, Rachael A.; Yarnall, Alison J.; Williams-Gray, Caroline H.; Macleod, Angus D.; Counsell, Carl E.; Tysnes, Ole-Bjørn; Alves, Guido Werner; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2022)Background: Common genetic variance in apolipoprotein E (APOE), β-glucocerebrosidase (GBA), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) has been linked to cognitive decline in Parkinson's disease (PD), ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2023)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Impulsive and compulsive behaviors in Parkinson's disease: Impact on quality of and satisfaction with life, and caregiver burden
Erga, Aleksander Hagen; Alves, Guido Werner; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy (Journal article; Peer reviewed, 2020)Introduction To disentangle the association between impulsive and compulsive behaviors (ICBs), health-related quality of life (HRQOL), satisfaction with life (SwL), and caregiver distress in dyads of people with Parkinson's ... -
The value of cerebrospinal fluid α‐synuclein and the tau/α‐synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology
Førland, Marthe Gurine; Tysnes, Ole-Bjørn; Aarsland, Dag; Maple-Grødem, Jodi; Pedersen, Kenn Freddy; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2019-07-10)Background and purpose: Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are three of the most common neurodegenerative disorders. Up to 20% of these patients have the wrong diagnosis, ...