Blar i Bergen Open Research Archive på forfatter "Pedersen, Line"

Viser treff 1-5 av 5

    • C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer 

      Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung; Pedersen, Line; Lepland, Johanna; Takle, Sina Thorsen; Madeleine, Noëlly; Peters, Stacey D'mello; Wogsland, Cara Ellen; Grøndal, Sturla Magnus; Lorens, James Bradley; Goodarzi, Hani; Lønning, Per Eystein; Knappskog, Stian; Molven, Anders; Halberg, Nils Henrik (Journal article; Peer reviewed, 2022)
      Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ...

    • Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions 

      Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara; Karlsen, Tine Veronica; Rygh, Cecilie Brekke; Curry, Fitz-Roy; Bakke, Marit; Reed, Rolf K.; Tenstad, Olav; Døskeland, Stein Ove (Journal article; Peer reviewed, 2020)
      Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ...

    • Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro 

      Velasco Pinto, Kelly; St-Louis, Johanna; Hovland, Henrikke N.; Thompson, Nels; Ottesen, Åsta; Choi, Man Hung; Pedersen, Line; Njølstad, Pål Rasmus; Arnesen, Thomas; Fjeld, Karianne; Aukrust, Ingvild; Myklebust, Line Merethe; Molven, Anders (Journal article; Peer reviewed, 2021)
      Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ...

    • High-dimensional immunotyping of tumors grown in obese and non-obese mice 

      Wogsland, Cara Ellen; Lien, Hilde Eide; Pedersen, Line; Hanjra, Pahul; Grøndal, Sturla Magnus; Brekken, Rolf A; Lorens, James Bradley; Halberg, Nils Henrik (Journal article; Peer reviewed, 2021)
      Obesity is a disease characterized by chronic low-grade systemic inflammation and has been causally linked to the development of 13 cancer types. Several studies have been undertaken to determine whether tumors evolving ...

    • Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy 

      Åsrud, Kathrine Sivertsen; Pedersen, Line; Æsøy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)
      The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ...