• Characterization of monolithic CMOS pixel sensor chip with ion beams for application in particle computed tomography 

      Tambave, Ganesh Jagannath; Alme, Johan; Barnaföldi, Gergely Gábor; Barthel, Rene; van den Brink, Anthony; Brons, Stephan; Chaar, Mamdouh; Eikeland, Viljar Nilsen; Genov, Georgi; Grøttvik, Ola Slettevoll; Pettersen, Helge Egil Seime; Pastuović̀, Željko; Huiberts, Simon; Helstrup, Håvard; Hetland, Kristin Fanebust; Mehendale, Shruti Vineet; Meric, Ilker; Malik, Qasim Waheed; Odland, Odd Harald; Papp, Gábor; Peitzmann, Thomas; Piersimoni, Pierluigi; Rehman, Attiq Ur; Reidt, Felix; Richter, Matthias; Røhrich, Dieter; Sudár, András; Samnøy, Andreas Tefre; Seco, Joao Carlos; Shafiee, Hesam; Skjæveland, Eivind Vågslid; Sølie, Jarle Rambo; Ullaland, Kjetil; Varga-Kofarago, Monika; Volz, Lennart; Wagner, Boris; Yang, Shiming (Peer reviewed; Journal article, 2019)
      Particle computed tomography (pCT) is an emerging imaging modality that promises to reduce rangeuncertainty in particle therapy. The Bergen pCT collaboration aims to develop a novel pCT prototype basedon the ALPIDE monolithic ...
    • A Digital Tracking Calorimeter for Proton Computed Tomography 

      Pettersen, Helge Egil Seime (Doctoral thesis, 2018-05-29)
      Cancer is a destructive disease, in which tumor cells grow out-of-control, halting organ function. Its treatment is threefold: Radical surgery, chemotherapy and radiation therapy. Their relative usage is determined by ...
    • Enhancing Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer Patients with iCE, a Novel System for Automated Multi-Criterial Treatment Planning Including Beam Angle Optimization 

      Fjellanger, Kristine; Hysing, Liv Bolstad; Heijmen, Ben J.M.; Pettersen, Helge Egil Seime; Sandvik, Inger Marie; Sulen, Turid Husevåg; Breedveld, Sebastiaan; Rossi, Linda (Journal article; Peer reviewed, 2021)
      In this study, the novel iCE radiotherapy treatment planning system (TPS) for automated multi-criterial planning with integrated beam angle optimization (BAO) was developed, and applied to optimize organ at risk (OAR) ...
    • Helium radiography with a digital tracking calorimeter—a Monte Carlo study for secondary track rejection 

      Pettersen, Helge Egil Seime; Volz, Lennart; Sølie, Jarle Rambo; Alme, Johan; Barnaföldi, Gergely Gábor; Barthel, Rene; van den Brink, Anthony; Borshchov, Vyacheslav; Chaar, Mamdouh; Eikeland, Viljar Nilsen; Genov, Georgi; Grøttvik, Ola Slettevoll; Helstrup, Håvard; Keidel, Ralf; Kobdaj, Chinorat; van der Kolk, Naomi; Mehendale, Shruti Vineet; Meric, Ilker; Odland, Odd Harald; Papp, Gábor; Peitzmann, Thomas; Piersimoni, Pierluigi; Protsenko, Maksym; Rehman, Attiq Ur; Richter, Matthias; Samnøy, Andreas Tefre; Seco, Joao; Shafiee, Hesam; Songmoolnak, Arnon; Tambave, Ganesh Jagannath; Tymchuk, Ihor; Ullaland, Kjetil; Varga-Kofarago, Monika; Wagner, Boris; Xiao, Renzheng; Yang, Shiming; Yokoyama, Hiroki; Röhrich, Dieter Rudolf Christian (Journal article; Peer reviewed, 2021)
      Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, ...
    • The Higgs Boson in Less Constrained Supersymmetric Models 

      Pettersen, Helge Egil Seime (Master thesis, 2012-06-01)
      In this thesis, we explore the phenomenological minimal supersymmetric standard model (pMSSM) in the context of the Higgs boson. If the emerging results from the LHC are real, will the pMSSM be able to accommodate this? ...
    • A high-granularity digital tracking calorimeter optimized for proton CT 

      Alme, Johan; Barnaföldi, Gergely Gábor; Barthel, Rene; Borshchov, Vyacheslav; Bodova, Tea; van den Brink, Anthony; Brons, Stephan; Chaar, Mamdouh; Eikeland, Viljar Nilsen; Feofilov, Grigory; Genov, Georgi; Grimstad, Silje; Grøttvik, Ola Slettevoll; Helstrup, Håvard; Herland, Alf Kristoffer; Hilde, Annar Eivindplass; Igolkin, Sergey; Keidel, Ralf; Kobdaj, Chinorat; van der Kolk, Naomi; Listratenko, Oleksandr; Malik, Qasim Waheed; Mehendale, Shruti Vineet; Meric, Ilker; Nesbø, Simon Voigt; Odland, Odd Harald; Papp, Gábor; Peitzmann, Thomas; Pettersen, Helge Egil Seime; Piersimoni, Pierluigi; Protsenko, Maksym; Rehman, Attiq Ur; Richter, Matthias; Røhrich, Dieter; Samnøy, Andreas Tefre; Seco, Joao; Setterdahl, Lena; Shafiee, Hesam; Skjolddal, Øistein Jelmert; Solheim, Emilie Haugland; Songmoolnak, Arnon; Sudár, Ákos; Sølie, Jarle Rambo; Tambave, Ganesh Jagannath; Tymchuk, Ihor; Ullaland, Kjetil; Underdal, Håkon Andreas; Varga-Kofarago, Monika; Volz, Lennart; Wagner, Boris; Widerøe, Fredrik Mekki; Xiao, RenZheng; Yang, Shiming; Yokoyama, Hiroki (Journal article; Peer reviewed, 2020)
      A typical proton CT (pCT) detector comprises a tracking system, used to measure the proton position before and after the imaged object, and an energy/range detector to measure the residual proton range after crossing the ...
    • Image quality of list-mode proton imaging without front trackers 

      Sølie, Jarle Rambo; Volz, Lennart; Pettersen, Helge Egil Seime; Piersimoni, Pierluigi; Odland, Odd Harald; Røhrich, Dieter; Helstrup, Håvard; Peitzmann, Thomas; Ullaland, Kjetil; Varga-Kofarago, Monika; Mehendale, Shruti Vineet; Grøttvik, Ola Slettevoll; Eikeland, Viljar Nilsen; Meric, Ilker; Seco, Joao (Journal article; Peer reviewed, 2020)
      List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one ...
    • In-situ measurements of rare earth elements in deep sea sediments using nuclear methods 

      Obhođaš, Jasmina; Sudac, Davorin; Meric, Ilker; Pettersen, Helge Egil Seime; Uroić, Milivoj; Nađ, Karlo; Valković, Vlado (Peer reviewed; Journal article, 2018-03-21)
      The prospecting activities for finding new rare earth elements (REE) sources have increased greatly in recent years. One of the main discoveries was announced in 2011 by Japanese researchers who found large quantities of ...
    • Mixed Effect Modeling of Dose and Linear Energy Transfer Correlations With Brain Image Changes After Intensity Modulated Proton Therapy for Skull Base Head and Neck Cancer 

      Engeseth, Grete May; He, Renjie; Mirkovic, Dragan; Yepes, Pablo; Mohamed, Abdallah Sherif Radwan; Stieb, Sonja; Fuller, Clifton Dave; Wu, Richard; Zhang, Xiadong; Hysing, Liv Bolstad; Pettersen, Helge Egil Seime; Stokkevåg, Camilla Hanquist; Mohan, Radhe; Frank, Steven Jay; Gunn, Gary Brandon (Journal article; Peer reviewed, 2021)
      Purpose Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head and neck cancers at the skull base this could potentially ...
    • Optic nerve constraints for carbon ion RT at CNAO ? Reporting and relating outcome to European and Japanese RBE 

      Dale, Jon Espen; Molinelli, Silvia; Vitolo, Viviana; Vischioni, Barbara; Bonora, Maria; Magro, Giuseppe; Pettersen, Helge Egil Seime; Mairani, Andrea; Hasegawa, Azusa; Dahl, Olav; Valvo, Francesca; Fossati, Piero (Peer reviewed; Journal article, 2019)
      Background and purpose: Until now, carbon ion RT (CIRT) dose constraints for the optic nerve (ON) have only been validated and reported in the NIRS RBE-weighted dose (DNIRS). The aim of this work is to improve CNAO’s ...
    • Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors 

      Otterlei, Ole Marius; Indelicato, Daniel J.; Toussaint, Laura; Ytre-Hauge, Kristian; Pilskog, Sara; Fjæra, Lars Fredrik; Rørvik, Eivind; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Di Pinto, Marcos; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)
      Background Clinically, a constant value of 1.1 is used for the relative biological effectiveness (RBE) of protons, whereas in vitro the RBE has been shown to vary depending on physical dose, tissue type, and linear energy ...