• Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia 

      Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel; Sulen, Andre; Popa, Mihaela Lucia; Sørnes, Steinar; Reikvam, Håkon; Chan, Kok-Ping; Hovland, Randi; McCormack, Emmet; Bruserud, Øystein; Myers, Andrew G.; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-12-01)
      Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ...
    • CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma 

      Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari; Popa, Mihaela Lucia; Akslen, Lars A.; Gjertsen, Bjørn Tore; Karlsen, Ida; Fosse, Vibeke Samuelsen; Bjørge, Line; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) ...
    • First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma 

      Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten; Molven, Anders; Gjertsen, Bjørn Tore; Bjørge, Line; McCormack, Emmet (Peer reviewed; Journal article, 2014-03-04)
      Purpose: Preclinical models of epithelial ovarian cancer have not been exploited to evaluate the clinical standard combination therapy of surgical debulking with follow-up chemotherapy. As surgery is critical to patient ...
    • The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer 

      Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina; Gjertsen, Bjørn Tore; McCormack, Emmet; Bjørge, Line (Peer reviewed; Journal article, 2016-06-28)
      Background: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the ...
    • Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma 

      Haldorsen, Ingfrid S.; Popa, Mihaela Lucia; Fonnes, Tina; Brekke, Njål; Kopperud, Reidun Kristin; Visser, Nicole C.; Rygh, Cecilie Brekke; Pavlin, Tina; Salvesen, Helga Birgitte; McCormack, Emmet; Krakstad, Camilla (Peer reviewed; Journal article, 2015-08-07)
      Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour characteristics ...