• Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients 

      Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)
      Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ...
    • Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity 

      Watne, Leiv Otto; Idland, Ane-Victoria; Fekkes, Durk; Ræder, Johan; Frihagen, Frede Jon; Ranhoff, Anette Hylen; Chaudhry, Farrukh Abbas; Engedal, Knut; Wyller, Torgeir Bruun; Hassel, Bjørnar (Peer reviewed; Journal article, 2016-08-02)
      Background: To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum. Methods: In this prospective ...
    • Norske retningslinjer for tverrfaglig behandling av hoftebrudd 

      Figved, Wender; Frihagen, Frede; Johnsen, Lars Gunnar; Opheim, Inger; Aanderbakk, Dag Ole; Eri-Montsma, Astrid; Naalsund, Paal; Ranhoff, Anette Hylen; Saltvedt, Ingvild; Maini, Sameer; Sletvold, Olav; Sundin, Johan Bro; Torp, Audhild Egeland; Watne, Leiv Otto; Ræder, Johan; Sendstad, Karen Helene (Report, 2018)
      Hoftebrudd rammer cirka 9000 pasienter per år i Norge. Pasienter med hoftebrudd er ofte skrøpelige eldre personer som har mye komorbiditet og ikke minst geriatriske problemstillinger. Det er økt risiko for varig redusert ...
    • Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study 

      Neerland, Bjørn Erik; Krogseth, Maria; Juliebø, Vibeke; Ranhoff, Anette Hylen; Engedal, Knut; Frihagen, Frede Jon; Ræder, Johan; Wyller, Torgeir Bruun; Watne, Leiv Otto (Peer reviewed; Journal article, 2017-07-10)
      Background Delirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long ...