• Associations Between Natural Physiological and Supraphysiological Estradiol Levels and Stress Perception 

      Leeners, Brigitte; Krüger, Tillman H.C.; Geraedts, Kirsten; Tronci, Enrico; Mancini, Toni; Egli, Marcel; Röblitz, Susanna; Saleh, Lanja; Spanaus, Katharina; Schippert, Cordula; Zhang, Y; Ille, Fabian (Peer reviewed; Journal article, 2019-06-11)
      Stress is a risk factor for impaired general, mental, and reproductive health. The role of physiological and supraphysiological estradiol concentrations in stress perception and stress processing is less well understood. ...
    • Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization 

      Frank, Anna-Simone; Larripa, Kamila; Ryu, Hwayeon; Snodgrass, Ryan; Röblitz, Susanna (Journal article; Peer reviewed, 2020)
      In this paper, we present and analyze a mathematical model for polarization of a single macrophage which, despite its simplicity, exhibits complex dynamics in terms of multistability. In particular, we demonstrate that an ...
    • Macroscale mesenchymal condensation to study cytokine-driven cellular and matrix-related changes during cartilage degradation 

      Weber, Marie-Christin; Fischer, Lisa; Damerau, Alexandra; Ponomarev, Igor; Pfeiffenberger, Moritz; Gaber, Timo; Götschel, Sebastian; Lang, Jens; Röblitz, Susanna; Buttgereit, Frank; Ehrig, Rainald; Lang, Annemarie (Journal article; Peer reviewed, 2020)
      Understanding the pathophysiological processes of cartilage degradation requires adequate model systems to develop therapeutic strategies towards osteoarthritis (OA). Although different in vitro or in vivo models have been ...
    • Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation 

      Fischer, Sophie; Ehrig, Rainald; Schäfer, Stefan; Tronci, Enrico; Mancini, Toni; Egli, Marcel; Ille, Fabian; Krüger, Tillmann H. C.; Leeners, Brigitte; Röblitz, Susanna (Journal article; Peer reviewed, 2021)
      New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that ...
    • Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows 

      Omari, Mohamed; Lange, Alexander; Plöntzke, Julia; Röblitz, Susanna (Peer reviewed; Journal article, 2020)
      Background: Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production ...
    • Modeling of Multivalent Ligand-Receptor Binding Measured by kinITC 

      Erlekam, Franziska; Igde, Sinaida; Röblitz, Susanna; Hatmann, Laura; Weber, Marcus (Peer reviewed; Journal article, 2019)
      In addition to the conventional Isothermal Titration Calorimetry (ITC), kinetic ITC (kinITC) not only gains thermodynamic information, but also kinetic data from a biochemical binding process. Moreover, kinITC gives insights ...
    • Objective Priors in the Empirical Bayes Framework 

      Klebanov, Ilja; Sikorski, Alexander; Schütte, Christof; Röblitz, Susanna (Journal article; Peer reviewed, 2020)
      When dealing with Bayesian inference the choice of the prior often remains a debatable question. Empirical Bayes methods offer a data-driven solution to this problem by estimating the prior itself from an ensemble of data. ...