Blar i Bergen Open Research Archive på forfatter "Rørvik, Eivind"
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Analysis and Development of Phenomenological Models for the Relative Biological Effectiveness in Proton Therapy
Rørvik, Eivind (Doctoral thesis, 2019-08-23)Proton therapy is undergoing a rapid development making it increasingly popular as a treatment of cancer. Protons interact differently with the tissue compared to conventional radiation therapy with photons, resulting in ... -
The experimental dose ranges influence the LET_d dependency of the proton minimum RBE (RBE_min)
Rørvik, Eivind; Thørnqvist, Sara; Ytre-Hauge, Kristian (Peer reviewed; Journal article, 2019-09-23)Cell experiments have shown the proton relative biological effectiveness (RBE) to vary with dose and linear energy transfer (LET), which has led to development of variable RBE models. The RBE is normally estimated from two ... -
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ... -
Inter-patient variations in relative biological efectiveness for craniospinal irradiation with protons
Ytre-Hauge, Kristian; Fjæra, Lars Fredrik; Rørvik, Eivind; Dahle, Tordis Johnsen; Dale, Jon Espen; Pilskog, Sara; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2020)Cranio-spinal irradiation (CSI) using protons has dosimetric advantages compared to photons and is expected to reduce risk of adverse effects. The proton relative biological effectiveness (RBE) varies with linear energy ... -
The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy
Henjum, Helge; Dahle, Tordis Johnsen; Fjæra, Lars Fredrik; Rørvik, Eivind; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla H.; Mairani, Andrea; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2021)Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological ... -
Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors
Otterlei, Ole Marius; Indelicato, Daniel J.; Toussaint, Laura; Ytre-Hauge, Kristian; Pilskog, Sara; Fjæra, Lars Fredrik; Rørvik, Eivind; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Di Pinto, Marcos; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Background Clinically, a constant value of 1.1 is used for the relative biological effectiveness (RBE) of protons, whereas in vitro the RBE has been shown to vary depending on physical dose, tissue type, and linear energy ...