Browsing Bergen Open Research Archive by Author "Radzvilavicius, Arunas"

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Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck

Edwards, David; Røyrvik, Ellen Christine; Chustecki, Joanne; Giannakis, Konstantinos; Glastad, Robert Clay; Radzvilavicius, Arunas; Johnston, Iain (Journal article; Peer reviewed, 2021)

Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” ...
Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys

Radzvilavicius, Arunas; Johnston, Iain (Journal article; Peer reviewed, 2022)

Bioenergetic organelles—mitochondria and plastids—retain their own genomes (mtDNA and ptDNA), and these organelle DNA (oDNA) molecules are vital for eukaryotic life. Like all genomes, oDNA must be able to evolve to suit ...
Selection for biparental inheritance of mitochondria under hybridization and mitonuclear fitness interactions

Allison, Tom M.; Radzvilavicius, Arunas; Dowling, Damian K. (Journal article; Peer reviewed, 2021)

Uniparental inheritance (UPI) of mitochondria predominates over biparental inheritance (BPI) in most eukaryotes. However, examples of BPI of mitochondria, or paternal leakage, are becoming increasingly prevalent. Most ...