Blar i Bergen Open Research Archive på forfatter "Rajalahti, Tarja"
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Aerobic fitness and metabolic health in children: A clinical validation of directly measured maximal oxygen consumption versus performance measures as markers of health
Aadland, Eivind; Kvalheim, Olav Martin; Rajalahti, Tarja; Skrede, Turid; Resaland, Geir Kåre (Peer reviewed; Journal article, 2017-09)High aerobic fitness is consistently associated with a favorable metabolic health profile in children. However, measurement of oxygen uptake, regarded as the gold standard for evaluating aerobic fitness, is often not ... -
An approach to assess and adjust for the influence of multicollinear covariates on metabolomics association patterns-applied to a study of the associations between a comprehensive lipoprotein profile and the homeostatic model assessment of insulin resistance
Kvalheim, Olav Martin; Rajalahti, Tarja; Aadland, Eivind (Journal article; Peer reviewed, 2022)Introduction Comprehensive lipoprotein profiling using proton nuclear magnetic resonance (NMR) spectroscopy of serum represents an alternative to the homeostatic model assessment of insulin resistance (HOMA-IR). Both ... -
Associations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort study
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Journal article; Peer reviewed, 2022-01-21)Background: Our understanding of the mechanisms through which physical activity might benefit lipoprotein metabolism is inadequate. Here we characterise the continuous associations between physical activity of different ... -
Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Journal article; Peer reviewed, 2019)Background and aims: Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine ... -
Cardiometabolic associations between physical activity, adiposity, and lipoprotein subclasses in prepubertal norwegian children
Rajalahti, Tarja; Aadland, Eivind; Resaland, Geir Kåre; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin (Journal article; Peer reviewed, 2021)Lipoprotein subclasses possess crucial cardiometabolic information. Due to strong multicollinearity among variables, little is known about the strength of influence of physical activity (PA) and adiposity upon this ... -
Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging
Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin (Peer reviewed; Journal article, 2016-03)Concentrations in serum were determined for 18 fatty acids (FAs) and 21 lipoprotein main and subclasses by chromatographic analyses and the average size was calculated for very low density (VLDL), low density (LDL) and ... -
Cross-sectional and prospective associations between aerobic fitness and lipoprotein particle profile in a cohort of Norwegian schoolchildren
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Journal article; Peer reviewed, 2021)Background and aims The associations between aerobic fitness and traditional measures of lipid metabolism in children are uncertain. We investigated whether higher levels of aerobic fitness benefit lipoprotein metabolism ... -
Identifying possible biomarkers of lower urinary tract symptoms using metabolomics and partial least square regression
Hopland-Nechita, Florin Vasile; Andersen, John Roger; Rajalahti, Tarja; Andreassen, Trygve; Beisland, Christian (Journal article; Peer reviewed, 2023)Introduction The objective of this study was to explore potential novel biomarkers for moderate to severe lower urinary tract symptoms (LUTS) using a metabolomics-based approach, and statistical methods with significant ... -
Influence of adiposity and physical activity on the cardiometabolic association pattern of lipoprotein subclasses to aerobic fitness in prepubertal children
Rajalahti, Tarja; Aadland, Eivind; Resaland, Geir Kåre; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin (Journal article; Peer reviewed, 2021)Aerobic fitness (AF) and lipoprotein subclasses associate to each other and to cardiovascular health. Adiposity and physical activity (PA) influence the association pattern of AF to lipoproteins almost inversely making it ... -
Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels
Lin, Chenchen; Andersen, John Roger; Våge, Villy; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin (Peer reviewed; Journal article, 2016-08)Serum fatty acid (FA) levels were monitored in women with severe obesity during intensive lifestyle intervention. At baseline, total FA levels and most individual FAs were elevated compared to a matching cohort of normal ... -
Number of components and prediction error in partial least squares regression determined by Monte Carlo resampling strategies
Kvalheim, Olav Martin; Grung, Bjørn; Rajalahti, Tarja (Peer reviewed; Journal article, 2019)Using a metabolomics data set with 1057 serum samples, we designed and assessed different procedures based on Monte Carlo resampling schemes to determine the optimal number of components to be included in partial least ... -
Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health
Lin, Chenchen; Rajalahti, Tarja; Mjøs, Svein Are; Kvalheim, Olav Martin (Peer reviewed; Journal article, 2016-01)A battery of methods for multivariate data analysis has been used to assess the associations between concentrations of fatty acids (FAs) and lipoprotein subclasses and particle size in serum for a normolipidemic population ... -
Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children
Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are; Kvalheim, Olav Martin (Peer reviewed; Journal article, 2016-03)Introduction The lipid metabolism is one of the most important and complex processes in the body. Serum concentrations of 18 fatty acids (FAs) and 24 lipoprotein features, i.e. concentrations of lipoprotein main and ...