• Breathlessness across generations: results from the RHINESSA generation study 

      Ekström, Magnus; Johannessen, Ane; Abramson, Michael J.; Benediktsdóttir, Bryndís; Franklin, Karl A.; Gislason, Thorarinn; Real, Francisco Gomez; Holm, Mathias; Janson, Christer; Jogi, Rain; Lowe, Adrian J.; Malinovschi, Andrei; Martínez-Moratalla, Jesús; Oudin, Anna; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      Background Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated ...
    • Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status 

      Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost; Schlunnsen, Vivi; Jogi, Rain; Raherison, Chantal; Gislasson, Thorainn; Demoly, Pascal; Heinrich, Joachim; Nowak, Dennis; Corsico, Angelo; Accordini, Simone; Marcon, Alessandro; Squillacioti, Giulia; Olivieri, Mario; Nielsen, Rune; Johannessen, Ane; Real, Francisco Gomez; Garcia-Aymerich, Judith; Urrutia, Isabel; Pereira-Vega, Antonio; Gullón, José-Antonio; Olin, Anna-Carin; Forsberg, Bertil; Emilsson, Össur Ingi; Pin, Isabelle; Jarvis, Deborah; Janson, Christer; Malinovschi, Andrei (Journal article; Peer reviewed, 2021)
      Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and ...
    • Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization 

      Krantz, Christina; Accordini, Simone; Alving, Kjell; Corsico, Angelo G.; Demoly, Pascal; Ferreira, Diogenes S.; Forsberg, Bertil; Garcia-Aymerich, Judith; Gislason, Thorarinn; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Nerpin, Elisabet; Nowak, Dennis; Olin, Anna-Carin; Olivieri, Mario; Pereira-Vega, Antonio; Raherison-Semjen, Chantal; Real, Francisco Gomez; Sigsgaard, Torben; Squillacioti, Giulia; Janson, Christer; Malinovschi, Andrei (Journal article; Peer reviewed, 2022)
      Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitization as a major determinant. Objective: We aimed to ...
    • CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test 

      Wåtevik, Marie; Frisk, Bente; Real, Francisco Gomez; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal Lind; Johannessen, Ane (Journal article; Peer reviewed, 2021)
      Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ...
    • The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? 

      López Cervantes, Juan Pablo; Lønnebotn, Marianne; Jögi, Nils Oskar; Calciano, Lucia; Kuiper, Ingrid Nordeide; Darby, Matthew G; Dharmage, Shyamali Chandrika; Real, Francisco Gomez; Hammer, Barbara; Bertelsen, Randi Jacobsen; Johannessen, Ane; Würtz, Anne Mette Lund; Knudsen, Gerd Toril Mørkve; Koplin, Jennifer; Pape, Kathrine; Skulstad, Svein Magne; Timm, Signe; Tjalvin, Gro; Krauss-Etschmann, Susanne; Accordini, Simone; Schlünssen, Vivi; Kirkeleit, Jorunn; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering ...
    • Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study 

      Vindenes, Hilde Kristin; Svanes, Cecilie; Lygre, Stein Håkon Låstad; Real, Francisco Gomez; Ringel-Kulka, Tamar; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2021)
      Background Many phenols and parabens are applied in cosmetics, pharmaceuticals and food, to prevent growth of bacteria and fungi. Whether these chemicals affect inflammatory diseases like allergies and overweight is largely ...
    • Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies 

      Svanes, Cecilie; Bertelsen, Randi Jacobsen; Accordini, Simone; Holloway, John W.; Juliusson, Pétur Benedikt; Boateng, Eistine; Krauss-Etchmann, Susanne; Schlünssen, Vivi; Real, Francisco Gomez; Skulstad, Svein Magne (Journal article; Peer reviewed, 2021)
      Emerging evidence suggests that exposures in prepuberty, particularly in fathers-to-be, may impact the phenotype of future offspring. Analyses of the RHINESSA cohort find that offspring of father’s exposed to tobacco smoking ...
    • Lifelong exposure to residential greenspace and the premenstrual syndrome: A population-based study of Northern European women 

      Triebner, Kai Philipp; Markevych, Iana; Bertelsen, Randi Jacobsen; Skottvoll, Bente Sved; Hustad, Simon Steinar; Forsberg, Bertil; Franklin, Karl A; Holm, Mathias; Lindberg, Eva; Heinrich, Joachim; Real, Francisco Gomez; Dadvand, Payam (Journal article; Peer reviewed, 2022)
      Background: The premenstrual syndrome (PMS) causes clinically relevant psychological and physical symptoms in up to 20% of women of reproductive age. To date, no studies have investigated the relationship between PMS and ...
    • Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma 

      Tjalvin, Gro; Svanes, Øistein; Igland, Jannicke; Bertelsen, Randi Jacobsen; Benediktsdóttir, Bryndís; Dharmage, Shyamali; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Johannessen, Ane; Malinovschi, Andrei; Pape, Kathrine; Real, Francisco Gomez; Sigsgaard, Torben; Torén, Kjell; Vindenes, Hilde Kristin; Zock, Jan-Paul; Schlünssen, Vivi; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Background Emerging research suggests health effects in offspring after parental chemical exposures before conception. Many future mothers are exposed to potent chemicals at work, but potential offspring health effects ...
    • Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study 

      Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland; Skulstad, Svein Magne; Real, Francisco Gomez; Lønnebotn, Marianne; Løvvik, Tone Shetelig; Vanky, Eszter; Kessler, Jørg (Journal article; Peer reviewed, 2022-01-28)
      Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ...
    • Parental Prepuberty Overweight and Offspring Lung Function 

      Lønnebotn, Marianne; Calciano, Lucia; Johannessen, Ane; Jarvis, Deborah L; Abramson, Michael J.; Benediktsdottir, Bryndis; Bråbäck, Lennart; Franklin, Karl A.; Godoy, Raúl; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Kirkeleit, Jorunn; Malinovschi, Andrei; Pereira-Vega, Antonio; Schlunssen, Vivi; Dharmage, Shyamali C.; Accordini, Simone; Real, Francisco Gomez; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and ...
    • Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study 

      Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer; Abramson, Michael J.; Benediktsdóttir, Bryndís; Malinovschi, Andrei; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Real, Francisco Gomez; Schlünssen, Vivi; Jögi, Nils Oskar; Sánchez-Ramos, José Luis; Holm, Mathias; Garcia-Aymerich, Judith; Forsberg, Bertil; Svanes, Cecilie; Johannessen, Ane (Journal article; Peer reviewed, 2020)
      Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index ...
    • Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach 

      Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Benediktsdóttir, Bryndis; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali C.; Forsberg, Bertil; Real, Francisco Gomez; Holloway, John W.; Holm, Mathias; Janson, Christer; Jõgi, Nils O.; Jõgi, Rain; Malinovschi, Andrei; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Torén, Kjell; Jarvis, Deborah; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very ...
    • Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS) 

      Triebner, Kai; Bifulco, Ersilia; Barrera-Gómez, Jose; Basagaña, Xavier; Benediktsdóttir, Bryndís; Forsberg, Bertil; Franklin, Karl A.; Garcia-Larsen, Vanessa; Leynaert, Bénédicte; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren-Agirre, Nerea; Pin, Isabelle; Raherison, Chantal; Pereira-Vega, Antonio; Schlünssen, Vivi; Valentin, Antonia; Hustad, Steinar; Real, Francisco Gomez; Dadvand, Payam (Journal article; Peer reviewed, 2021)
      Background Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites ...