Browsing Bergen Open Research Archive by Author "Reikvam, Håkon"
Now showing items 1-20 of 71
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An Abrupt Transition to Digital Teaching—Norwegian Medical Students and Their Experiences of Learning Output during the Initial Phase of the COVID-19 Lockdown
Helland, Henriette Kronstad; Tylleskär, Thorkild; Kvernenes, Monika; Reikvam, Håkon (Journal article; Peer reviewed, 2022)Norwegian universities closed almost all on-campus activities on the 12 March 2020 following a lockdown decision of the Norwegian government in response to the COVID-19 pandemic. Online and digital teaching became the ... -
Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1
Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Peer reviewed; Journal article, 2017-09-01)Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ... -
Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel; Sulen, Andre; Popa, Mihaela Lucia; Sørnes, Steinar; Reikvam, Håkon; Chan, Kok-Ping; Hovland, Randi; McCormack, Emmet; Bruserud, Øystein; Myers, Andrew G.; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-12-01)Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ... -
Basosquamous Basal Cell Carcinoma with Bone Marrow Metastasis
Thunestvedt, Lise Mayrin Økland; Helgeland, Lars; Bachmann, Ingeborg Margrethe; Karlsdottir, Åsa; Haslerud, Torjan Magne; Reikvam, Håkon (Journal article; Peer reviewed, 2022-03-23)Basal cell carcinoma (BCC) is the most common cancer in Caucasians. It is slow growing and rarely metastasizes. If left untreated over time, invasive growth can occur. We present a patient case with a primary BCC located ... -
Carbapenem-Resistant Enterobacteriaceae—Implications for Treating Acute Leukemias, a Subgroup of Hematological Malignancies
Storhaug, Kristin Ølfarnes; Skutlaberg, Dag Harald; Hansen, Bent Are; Reikvam, Håkon; Wendelbo, Øystein (Journal article; Peer reviewed, 2021)Acute leukemias (AL) are a group of aggressive malignant diseases associated with a high degree of morbidity and mortality. Patients with AL are highly susceptible to infectious diseases due to the disease itself, factors ... -
Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia
Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2023)The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid ... -
CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors
Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (Peer reviewed; Journal article, 2017-03-11)Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ... -
Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation
Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik; Hovland, Randi; Gedde-Dahl, Tobias; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2018-09-23)Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1. Allogeneic stem cell transplantation (allo-SCT) was ... -
Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis
Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-14)Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin ... -
Concomitant Hemophagocytic Lymphohistiocytosis and Cytomegalovirus Disease: A Case Based Systemic Review
Rolsdorph, Linn; Mosevoll, Knut Anders; Helgeland, Lars; Reikvam, Håkon (Journal article; Peer reviewed, 2022)Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune mediated life-threatening condition. It is driven by an overactivation of the immune system and causes inflammatory tissue damage potentially leading to ... -
COVID-19 and venous thromboembolism - prophylaxis and treatment
Kvåle, Reidar; Azrakhsh, , Nessar Ahmad; Mohn, Kristin Greve-Isdahl; Aanerud, Marianne; Guttormsen, Anne Berit; Reikvam, Håkon (Journal article; Peer reviewed, 2020) -
Cytokine release syndrome in the immunotherapy of hematological malignancies: The biology behind and possible clinical consequences
Tvedt, Tor Henrik Anderson; Vo, Anh Khoi; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, ... -
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells
Reikvam, Håkon; Brenner, Annette; Hagen, Karen Marie; Liseth, Knut; Skrede, Silje; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-11)Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk ... -
Cytokines, adhesion molecules, and matrix metalloproteases as predisposing, diagnostic, and prognostic factors in venous thrombosis
Mosevoll, Knut Anders; Johansen, Silje; Wendelbo, Øystein; Nepstad, Ina; Bruserud, Øystein; Reikvam, Håkon (Peer reviewed; Journal article, 2018-05-22)The inflammatory response is a well-established part of, and a prerequisite for, venous thrombosis. To better understand the pathophysiology of venous thrombosis and to identify improved diagnostic biomarkers, further ... -
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ... -
Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid
Ersvær, Elisabeth; Brenner, Annette; Vetås, Kristin; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2015-05-02)Background: Cytarabine is used in the treatment of acute myeloid leukemia (AML). Low-dose cytarabine can be combined with valproic acid and all-trans retinoic acid (ATRA) as AML-stabilizing treatment. We have investigated ... -
Effects of the Autophagy-Inhibiting Agent Chloroquine on Acute Myeloid Leukemia Cells; Characterization of Patient Heterogeneity
Grønningsæter, Ida Sofie; Reikvam, Håkon; Aasebø, Elise; Bartaula-Brevik, Sushma; Hernandez‐valladares, Maria; Selheim, Frode; Berven, Frode Steingrimsen; Tvedt, Tor Henrik; Bruserud, Øystein; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2021)Autophagy is a highly conserved cellular degradation process that prevents cell damage and promotes cell survival, and clinical efforts have exploited autophagy inhibition as a therapeutic strategy in cancer. Chloroquine ... -
Eksamensformer i de norske medisinstudiene
Raaheim, Ole Farestvedt; Raaheim, Dag Farestvedt; Reikvam, Håkon; Kvernenes, Monika (Journal article; Peer reviewed, 2022)BAKGRUNN Det finnes ingen samlet oversikt over hvilke eksamensformer som er i bruk i de norske medisinstudiene. I denne studien har vi kartlagt hvilke eksamensformer som er i bruk, og analysert studieledelsenes begrunnelser ... -
Endocan in Acute Leukemia: Current Knowledge and Future Perspectives
Reikvam, Håkon; Hatfield, Kimberley Joanne; Wendelbo, Øystein; Lindås, Roald; Lasalle, Phillip; Bruserud, Øystein (Journal article; Peer reviewed, 2022)Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high ... -
Febrile Neutropenia in Acute Leukemia. Epidemiology, Etiology, Pathophysiology and Treatment
Hansen, Bent Are; Wendelbo, Øystein; Bruserud, Øyvind; Hemsing, Anette Lodvir; Mosevoll, Knut Anders; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Acute leukemias are a group of aggressive malignant diseases associated with a high degree of morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are ...